SEARCHCROSS-SECTIONALpulmonology, epidemiology

cross-sectional·pulmonology, epidemiology, cardiology, public health, nutrition·PMC10632896

Association between serum high-density lipoprotein cholesterol and lung function in adults: three cross-sectional studies from US and Korea National Health and Nutrition Examination Survey

BMJ Open Respiratory Research · 4 authors, 4 centres

AI SUMMARY

FIDELITY 100%

POPULATIONAdults from the US (NHANES III, NHANES 2007–2012) and South Korea (KNHANES IV–VII)

INTERVENTIONObservation of serum HDL cholesterol levels

COMPARISONCategorized into normal, high, and low HDL-C groups based on NCEP-ATP III guidelines

This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.

AGENT 01 · STRUCTURED SUMMARY

TRACE TO SOURCE

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TL;DR

This study analyzed data from three large national surveys in the US and South Korea to examine the relationship between serum HDL cholesterol levels and lung function.

Full summary

674 CHARS

The study performed a secondary analysis of three large, nationally representative cross-sectional surveys: two US NHANES cohorts (1988-1994, 2007-2012) and the Korean KNHANES. Using multivariate linear regression models adjusted for age, sex, BMI, smoking, and other confounders, the researchers examined the association between serum HDL cholesterol levels and lung function (FVC and FEV1). The cross-sectional design limits the ability to infer causality, and potential confounding from lifestyle or pre-existing diseases cannot be fully excluded. The findings suggest a robust association, but longitudinal studies are needed to confirm causality and explore mechanisms.

PICO

PPOPULATION

Adults from the US (NHANES III, NHANES 2007–2012) and South Korea (KNHANES IV–VII)

IINTERVENTION

Observation of serum HDL cholesterol levels

OOUTCOME

Lung function measured by percent predicted forced vital capacity (FVC) and forced expiratory volume in 1 second (FEV1)

STUDY TYPE

cross-sectional

SPECIALTY

pulmonology

SUMMARISED BY

AI pipeline

FIDELITY CHECK

100% · A

ORIGINAL PAPER

PMC10632896

Association between serum high-density lipoprotein cholesterol and lung function in adults: three cross-sectional studies from US and Korea National Health and Nutrition Examination Survey

BMJ Open Respiratory Research

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ABSTRACT

Introduction Cholesterol is an irreplaceable nutrient in pulmonary metabolism; however, studies on high-density lipoprotein cholesterol (HDL-C) levels have shown conflicting results regarding lung function. Therefore, we investigated the association between lung function and HDL-C levels in three cross-sectional studies conducted in the USA and South Korea. Methods US National Health and Nutrition Examination Survey (NHANES) III, US NHANES 2007–2012, and Korea National Health and Nutrition Examination Survey (KNHANES) IV–VII performed spirometry and met the American Thoracic Society recommendations. Multiple linear regression models were used to determine the relationship between serum lipid levels and lung function. The models were adjusted for age, sex, household income, body mass index, smoking pack year, use of lipid-lowering medication and race. Serum HDL-C levels were classified into three groups to assess the dose–response relationship according to the guideline from the National Cholesterol Education Program-Adult Treatment Panel III. Results The adult participants of the KNHANES (n=31 288), NHANES III (n=12 182) and NHANES 2007–2012 (n=9122) were analysed. Multivariate linear regression analysis of the serum cholesterol profiles revealed that only serum HDL-C was associated with forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV 1 ) in all three studies. A 1 SD increase in the HDL-C level increased the percent predicted FVC by 0.5%–1.5% p, and the per cent predicted FEV 1 by 0.5%–1.7% p. In terms of HDL-C levels, correlations between the HDL-C groups and the per cent predicted FVC and FEV 1 showed dose–response relationships. Compared with the normal group, high HDL-C levels increased FVC by 0.75%–1.79% p and FEV 1 by 0.55%–1.90% p, while low levels led to 0.74%–2.19% p and 0.86%–2.68% p reductions in FVC and FEV 1 , respectively. Subgroup analyses revealed weaker associations in females from KNHANES and NHANES III. Conclusion In the three nationwide cross-sectional studies, high HDL-C levels were associated with improved FVC and FEV 1 . However, future studies are needed to confirm this correlation and elucidate the underlying mechanisms.

CITATION EXPORT

Chanho Lee, Youngjae Cha, Soo Han Bae et al.. Association between serum high-density lipoprotein cholesterol and lung function in adults: three cross-sectional studies from US and Korea National Health and Nutrition Examination Survey. BMJ Open Respiratory Research. (2023). https://doi.org/10.1136/bmjresp-2023-001792

AUTHORS

4 · 4 CENTRES

Chanho Lee, Youngjae Cha, Soo Han Bae, Young Sam Kim

1Department of Biomedical Sciences, Yonsei University College of Medicine, Seoul, South Korea
2Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea
3Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
4Department of Biomedical Sciences, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, South Korea