Nutrients · 10 authors, 3 centres
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This systematic review and meta-analysis of four observational studies (119,755 participants) found that lower serum magnesium concentration was associated with a higher risk of incident fractures. The association was observed across studies in European cohorts and Japanese dialysis patients, with a consistent direction of effect.
All included studies were of high quality (Newcastle-Ottawa Scale score of 9). The meta-analysis found a consistent association between lower serum magnesium concentrations and higher risk of incident fractures across study populations. Two of the four included studies were conducted in patients undergoing dialysis, a population with altered magnesium homeostasis. A major limitation is the small number of eligible studies and the inclusion of two dialysis-specific cohorts, which may limit generalizability to the general population.
