Association between triglyceride glucose-body mass index and cardiovascular outcomes in patients undergoing percutaneous coronary intervention: a retrospective study

Cardiovascular Diabetology · 7 authors, 3 centres

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The addition of TyG-BMI to traditional risk factor models did not improve risk prediction for MACCEs in these subgroups.

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The addition of TyG-BMI to traditional risk factor models did not improve risk prediction for MACCEs in these subgroups.

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cohort

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cardiology

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ORIGINAL PAPER

PMC10064664

Association between triglyceride glucose-body mass index and cardiovascular outcomes in patients undergoing percutaneous coronary intervention: a retrospective study

Cardiovascular Diabetology

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ABSTRACT

Background The triglyceride glucose-body mass index (TyG-BMI index) has been considered a reliable surrogate measure of insulin resistance; however, its ability to predict the incidence of cardiovascular disease in individuals with coronary artery disease (CAD) remains uncertain. The aim of this study was to demonstrate the correlation between the TyG-BMI index and cardiovascular incidence. Methods A total of 2533 consecutive participants who underwent percutaneous coronary intervention (PCI) and drug-eluting stent (DES) implantation were included. Data from 1438 patients was analyzed in the study. The endpoint was defined as a composite of acute myocardial infarction, repeat revascularization, stroke, and all-cause mortality (major adverse cardiac and cerebrovascular events, MACCEs) at 34-month follow-up. The formula for calculating the TyG-BMI index is ln [fasting triglyceride (mg/dL) × fasting blood glucose (mg/dL)/2] × BMI. Results Among the 1438 participants, 195 incident patient cases of MACCEs were ascertained. The incidence of MACCEs showed no statistically significant differences in the TyG-BMI index tertiles in the overall population. Further exploratory subgroup analysis and multivariable logistic regression analysis revealed a linear relationship between the TyG-BMI index (per 1 SD increased) and MACCEs in the elderly patients (OR = 1.22, 95% CI 1.011–1.467, p = 0.038) and in the female patients (OR = 1.33, 95% CI 1.004–1.764, p = 0.047). The addition of the TyG-BMI index to traditional risk factor models in elderly and female patients did not improve risk prediction for MACCEs. Conclusion A higher TyG-BMI index was proportionally related to an increased incidence of MACCEs in the elderly or female patients. However, the inclusion of the TyG-BMI index did not provide better predictive performance for MACCEs in the elderly, specifically in female patients. Supplementary Information The online version contains supplementary material available at 10.1186/s12933-023-01794-8.

CITATION EXPORT

Yang Cheng, Zhen Fang, Xinxin Zhang et al.. Association between triglyceride glucose-body mass index and cardiovascular outcomes in patients undergoing percutaneous coronary intervention: a retrospective study. Cardiovascular Diabetology. (2023). https://doi.org/10.1186/s12933-023-01794-8

AUTHORS

7 · 3 CENTRES

Yang Cheng, Zhen Fang, Xinxin Zhang, Yuchen Wen, Jiaqi Lu, Shenghu He, Bing Xu

1grid.268415.cClinical Medical College, Yangzhou University, Yangzhou, 225001 China
2grid.411971.b0000 0000 9558 1426Present Address: The Yangzhou School of Clinical Medicine, Dalian Medical University, Dalian, 116044 China
3grid.268415.cPresent Address: Department of Cardiology, Northern Jiangsu People’s Hospital, Yangzhou University, Yangzhou, 225001 China