SEARCHCROSS-SECTIONALepidemiology, public health

cross-sectional·epidemiology, public health, endocrinology, nutrition, observational study·PMC10548327

Association Between Urinary Bisphenols and Body Composition Among American Adults: Cross-Sectional National Health and Nutrition Examination Survey Study

JMIR Public Health and Surveillance · 19 authors, 2 centres

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TL;DR

No significant associations were found between BPF and any body composition parameter.

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599 CHARS

Multivariate linear regression models were used, adjusting for age, gender, race, socioeconomic factors, and lifestyle variables. After full adjustment, BPA was negatively associated with total lean mass (quartile 4 vs quartile 1: β=−11.08, P<.001) and appendicular lean mass (quartile 4: β=−4.80, P<.001), and positively associated with trunk fat and total fat (both P<.001). BPS was positively associated with BMI (quartile 4: β=1.15, P<.001) and negatively associated with total lean mass (quartile 4: β=−11.14, P=.005). BPF showed no significant associations with any body composition parameter.

STUDY TYPE

cross-sectional

SPECIALTY

epidemiology

SUMMARISED BY

AI pipeline

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100% · A

ORIGINAL PAPER

PMC10548327

Association Between Urinary Bisphenols and Body Composition Among American Adults: Cross-Sectional National Health and Nutrition Examination Survey Study

JMIR Public Health and Surveillance

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ABSTRACT

Background Bisphenol A (BPA), bisphenol S (BPS), and bisphenol F (BPF) are widely used in various consumer products. They are environmental contaminants with estrogenic properties that have been linked to various health outcomes. Understanding their impact on body composition is crucial for identifying potential health risks and developing preventive strategies. However, most current studies have only focused on their relationship with BMI. Objective This study aimed to investigate the association between urinary levels of BPA, BPS, and BPF and body composition, including BMI, lean mass, and fat mass, in a large population-based sample. Methods We conducted a cross-sectional analysis using data from the National Health and Nutrition Examination Survey 2003-2016. Body composition data were assessed using dual-energy X-ray absorptiometry, which provided precise measurements of lean mass, fat mass, and other indicators. We used multivariate linear regression models to estimate the associations, adjusting for potential confounders such as age, gender, race, socioeconomic factors, and lifestyle variables. Results The results revealed significant associations between bisphenol exposure and body composition. After adjusting for covariates, BPS showed a positive association with BMI, with quartiles 3 and 4 having 0.91 (95% CI 0.34-1.48) and 1.15 (95% CI 0.55-1.74) higher BMI, respectively, compared with quartile 1 ( P <.001). BPA was negatively associated with total lean mass (TLM) and appendicular lean mass, with quartiles 2, 3, and 4 having –7.85 (95% CI –11.44 to –4.25), –12.33 (95% CI –16.12 to –8.54), and –11.08 (95% CI –15.16 to –7.01) lower TLM, respectively, compared with quartile 1 ( P <.001). BPS was negatively associated with TLM, with quartiles 3 (β=–10.53, 95% CI –16.98 to –4.08) and 4 (β=–11.14, 95% CI –17.83 to –4.45) having significantly lower TLM ( P =.005). Both BPA and BPS showed a positive dose-response relationship with trunk fat (BPA: P =.002; BPS: P <.001) and total fat (BPA: P <.001; BPS: P =.01). No significant association was found between BPF and any body composition parameter. Conclusions This large-sample study highlights the associations between urinary levels of BPA and BPS and alterations in body composition, including changes in lean mass, fat mass, and regional fat distribution. These findings underscore the importance of understanding the potential health risks associated with bisphenol exposure and emphasize the need for targeted interventions to mitigate adverse effects on body composition.

CITATION EXPORT

Jiakun Li, Zilong Zhang, Chichen Zhang et al.. Association Between Urinary Bisphenols and Body Composition Among American Adults: Cross-Sectional National Health and Nutrition Examination Survey Study. JMIR Public Health and Surveillance. (2023). https://doi.org/10.2196/49652

AUTHORS

19 · 2 CENTRES

Jiakun Li, Zilong Zhang, Chichen Zhang, Qiyu Zhu, Jing Zhao, Hui Zong, Qi Deng, Jiaming Zheng, Erman Wu, Rongrong Wu, Tong Tang, Yihang Zhang, Qiaosen Dong, Yifan Li, Jiao Wang, Lu Yang, Shi Qiu, Bairong Shen, Qiang Wei

1 Department of Urology West China Hospital Sichuan University Chengdu China
2 Institutes for Systems Genetics Frontiers Science Center for Disease-related Molecular Network West China Hospital, Sichuan University Chengdu China

EDITOR / REVIEWER

Amaryllis Mavragani, Travis Sanchez, Leonidas H Duntas, Jiaqian Luo