Association between urinary iodine excretion, genetic disposition and fluid intelligence in children, adolescents and young adults: the DONALD study

European Journal of Nutrition · 5 authors, 3 centres

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TL;DR

A polygenic score for general cognitive function was also positively associated with fluid intelligence, but no evidence was found that genetic disposition modifies the iodine–intelligence association.

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The PGS was also positively associated with FI (β=2.3; P=0.03). The study used up to three urine samples rather than habitual iodine intake throughout childhood, and the sample may not be representative of the general population regarding socio-economic status.

STUDY TYPE

cohort

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pediatrics

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ORIGINAL PAPER

PMC10421824

Association between urinary iodine excretion, genetic disposition and fluid intelligence in children, adolescents and young adults: the DONALD study

European Journal of Nutrition

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ABSTRACT

Purpose Iodine deficiency increases the risk of cognitive impairment and delayed physical development in children. It is also associated with cognitive impairment in adults. Cognitive abilities are among the most inheritable behavioural traits. However, little is known about the consequences of insufficient postnatal iodine intake and whether the individual genetic disposition modifies the association between iodine intake and fluid intelligence in children and young adults. Methods The cultural fair intelligence test was used to assess fluid intelligence in the participants of the DONALD study ( n = 238; mean age, 16.5 [SD = 7.7] years). Urinary iodine excretion, a surrogate iodine intake marker, was measured in 24-h urine. Individual genetic disposition ( n = 162) was assessed using a polygenic score, associated with general cognitive function. Linear regression analyses were conducted to determine whether Urinary iodine excretion was associated with fluid intelligence and whether this association was modified by individual genetic disposition. Results Urinary iodine excretion above the age-specific estimated average requirement was associated with a five-point higher fluid intelligence score than that below the estimated average requirement ( P = 0.02). The polygenic score was positively associated with the fluid intelligence score ( β = 2.3; P = 0.03). Participants with a higher polygenic score had a higher fluid intelligence score. Conclusion Urinary iodine excretion above the estimated average requirement in childhood and adolescence is beneficial for fluid intelligence. In adults, fluid intelligence was positively associated with a polygenic score for general cognitive function. No evidence showed that the individual genetic disposition modifies the association between Urinary iodine excretion and fluid intelligence.

CITATION EXPORT

Christina-Alexandra Schulz, Leonie Weinhold, Matthias Schmid et al.. Association between urinary iodine excretion, genetic disposition and fluid intelligence in children, adolescents and young adults: the DONALD study. European Journal of Nutrition. (2023). https://doi.org/10.1007/s00394-023-03152-6

AUTHORS

5 · 3 CENTRES

Christina-Alexandra Schulz, Leonie Weinhold, Matthias Schmid, Markus M. Nöthen, Ute Nöthlings

1grid.10388.320000 0001 2240 3300Institute of Nutrition and Food Sciences, Nutritional Epidemiology, University of Bonn, Bonn, Germany
2grid.15090.3d0000 0000 8786 803XDepartment of Medical Biometry, Informatics and Epidemiology, University Hospital Bonn, University of Bonn, Bonn, Germany
3grid.15090.3d0000 0000 8786 803XInstitute of Human Genetics, School of Medicine, University of Bonn, University Hospital Bonn, Bonn, Germany