SEARCHCROSS-SECTIONALcardiology, epidemiology

cross-sectional·cardiology, epidemiology, public health, endocrinology·PMC10018101

Association between visceral adiposity index and heart failure: A cross‐sectional study

Clinical Cardiology · 10 authors, 1 centre

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TL;DR

VAI was calculated from BMI, waist circumference, triglycerides, and HDL cholesterol.

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VAI was calculated from BMI, waist circumference, triglycerides, and HDL cholesterol. The primary analysis found a per-unit increase in VAI was associated with a 4% increased odds of HF (OR 1.04, 95% CI 1.02–1.05). Subgroup analyses showed consistent associations across different populations.

STUDY TYPE

cross-sectional

SPECIALTY

cardiology

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100% · A

ORIGINAL PAPER

PMC10018101

Association between visceral adiposity index and heart failure: A cross‐sectional study

Clinical Cardiology

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ABSTRACT

Abstract Background Obesity is an important risk factor for heart failure (HF). Hypothesis Visceral adiposity index (VAI) is a simple metric for assessing obesity; however, the association between VAI and risk for HF has not been studied. Methods A cross‐sectional study involving 28 764 participants ≥18 years of age from the National Health and Nutrition Examination Survey (NHANES), 2009–2018, in the United States was performed. VAI was calculated using body mass index (BMI), waist circumference (WC), triglycerides (TG), and high‐density lipoprotein cholesterol. VAI was analyzed as a continuous and categorical variable to examine its association with HF. Subgroup analysis was also performed. Results The highest VAI (fourth quartile [Q4]) was found among males, BMI, systolic and diastolic blood pressure, WC, hypertension, diabetes, liver disease, coronary heart disease, smoking, total cholesterol, and TG. More participants in Q4 took β‐receptor blockers, angiotensin‐converting enzyme inhibitors/angiotensin II receptor blockers/angiotensin receptor‐neprilysin inhibitor, calcium channel blockers, and antidiabetic and antihyperlipidemic medications. Participants with HF exhibited greater VAI. A per‐unit increase in VAI resulted in a 4% increased risk for HF (odds ratio [OR] 1.04 [95% confidence interval (CI) 1.02–1.05]). After multivariable adjustment, compared with the lowest quartile, the OR for Q3 was 1.55 (95% CI 1.24–1.94). Subgroup analysis revealed no significant interactions between VAI and specific subgroups. Conclusion VAI was independently associated with the risk for HF. As a noninvasive index of visceral adiposity, VAI could be used for a “one shot” assessment of HF risk and may serve as a novel marker. Keywords: heart failure, VAI, visceral adiposity index, visceral fat

CITATION EXPORT

Xinyu Zhang, Yijun Sun, Ying Li et al.. Association between visceral adiposity index and heart failure: A cross‐sectional study. Clinical Cardiology. (2023). https://doi.org/10.1002/clc.23976

AUTHORS

10 · 1 CENTRES

Xinyu Zhang, Yijun Sun, Ying Li, Chengwei Wang, Yi Wang, Mei Dong, Jie Xiao, Zongwei Lin, Huixia Lu, Xiaoping Ji

1 Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China