BMJ Open Ophthalmology · 13 authors, 7 centres
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This prospective observational study analyzed 742 eyes from 379 women in the CAREDS2 cohort to investigate associations between baseline macular pigment optical density (MPOD) and retinal layer thicknesses measured approximately 15 years later.
This prospective observational study analyzed 742 eyes from 379 women in the CAREDS2 cohort to investigate associations between baseline macular pigment optical density (MPOD) and retinal layer thicknesses measured approximately 15 years later. In eyes without manifest primary open-angle glaucoma (POAG), higher MPOD was positively associated with thicker macular ganglion cell complex (GCC), ganglion cell layer (GCL), and inner plexiform layer (IPL) in the central subfield. Among eyes with manifest POAG, higher MPOD was positively associated with thicker central macular GCC, GCL, IPL, and retinal nerve fiber layer (RNFL), and with thicker peripapillary RNFL in the superior and temporal quadrants. The study was limited by its observational design, a predominantly white, non-Hispanic female cohort, and the potential for residual confounding.
