SEARCHCASE-CONTROLobstetrics and gynecology, nutrition

case-control·obstetrics and gynecology, nutrition, epidemiology, micronutrients, minerals·PMC10053178

Association of Maternal Plasma Manganese with the Risk of Spontaneous Preterm Birth: A Nested Case–Control Study Based on the Beijing Birth Cohort Study (BBCS) in China

Nutrients · 13 authors, 7 centres

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TL;DR

This nested case-control study analyzed repeated plasma manganese measurements from pregnant women in the Beijing Birth Cohort. It found that a high maternal plasma manganese level in the third trimester was positively associated with an increased risk of spontaneous preterm birth.

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The study measured plasma Mn in the first and third trimesters for SPB cases and term-birth controls. The central finding was that a high plasma Mn level in the third trimester (but not the first) was positively associated with increased SPB risk, with a dose-dependent relationship observed in the non-PROM subgroup. The effect was more pronounced in normal-weight women and women without premature rupture of membranes (PROM). The results suggest that monitoring Mn levels in pregnancy may be relevant for SPB prevention.

STUDY TYPE

case-control

SPECIALTY

obstetrics and gynecology

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ORIGINAL PAPER

PMC10053178

Association of Maternal Plasma Manganese with the Risk of Spontaneous Preterm Birth: A Nested Case–Control Study Based on the Beijing Birth Cohort Study (BBCS) in China

Nutrients

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ABSTRACT

Abstract We performed this study to clarify the dynamic changes in maternal manganese (Mn) concentration during pregnancy and its association with spontaneous preterm birth (SPB). A nested case–control study was conducted based on the Beijing Birth Cohort Study (BBCS) from 2018 to 2020. Singleton pregnancy women aged 18–44 ( n = 488) were involved in the study, including 244 cases of SPB and 244 controls. All of the participants provided blood samples twice (in their first and third trimesters). Inductively coupled plasma mass spectrometry (ICP-MS) was used for the laboratory analysis, and unconditional logistic regression was used for the statistical analysis. We found that the maternal Mn levels were significantly higher in the third trimester than those in the first trimester (median: 1.23 vs. 0.81 ng/mL). The SPB risk was increased to 1.65 (95% CI: 1.04–2.62, p = 0.035) in the highest Mn level (third tertile) in the third trimester, especially in normal-weight women (OR: 2.07, 95% CI: 1.18–3.61, p = 0.011) or non-premature rupture of membrane (PROM) women (OR: 3.93, 95% CI: 2.00–7.74, p < 0.001). Moreover, a dose-dependent relationship exists between the SPB risk and maternal Mn concentration in non-PROM women (P trend < 0.001). In conclusion, dynamic monitoring of maternal Mn level during pregnancy would be helpful for SPB prevention, especially in normal-weight and non-PROM women. Keywords: manganese, spontaneous preterm birth, repeated measurement, dynamic monitoring

CITATION EXPORT

Weiling Han, Wei Zheng, Aili Wang et al.. Association of Maternal Plasma Manganese with the Risk of Spontaneous Preterm Birth: A Nested Case–Control Study Based on the Beijing Birth Cohort Study (BBCS) in China. Nutrients. (2023). https://doi.org/10.3390/nu15061413

AUTHORS

13 · 7 CENTRES

Weiling Han, Wei Zheng, Aili Wang, Junxi Chen, Jia Wang, Junhua Huang, Hang An, Yuru Ma, Kexin Zhang, Ruihua Yang, Lailai Yan, Zhiwen Li, Guanghui Li

1Division of Endocrinology and Metabolism, Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China
2Beijing Maternal and Child Health Care Hospital, Beijing 100026, China
3Department of Obstetrics, Beijing Luhe Hospital, Capital Medical University, Beijing 101100, China
4Institute of Reproductive and Child Health, Peking University, Beijing 100191, China
5Key Laboratory of Reproductive Health, National Health Commission of the People’s Republic of China, Beijing 100191, China
6Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China
7Department of Laboratorial Science and Technology, School of Public Health, Peking University, Beijing 100191, China