Frontiers in Aging Neuroscience · 9 authors, 6 centres
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This cross-sectional study of elderly Chinese residents combined with a C57BL/6 mouse experiment found a strong negative correlation between urinary NDMA concentration and cognitive impairment, and that subchronic NDMA treatment impaired learning and memory in mice.
This study measured urinary NDMA concentrations in 383 elderly residents of Shenzhen and conducted behavioral tests on C57BL/6 mice treated with NDMA. In humans, urinary NDMA was detected in 55.4% of samples with a median concentration of 0.23 μg/L, and urinary NDMA showed a strong negative correlation with cognitive impairment. Mouse behavioral tests demonstrated that 60 days of NDMA treatment at 3 mg/kg reduced cognitive performance. However, the authors acknowledge that logistic regression analysis found NDMA concentration or detection frequency did not significantly contribute to the model, possibly because of sample size or confounding factors. In mice, no significant pathological changes were found in vulnerable brain areas and immunocytochemical indicators for abnormal neuroprotein deposition were not assessed. The authors state these preliminary findings require confirmation.
