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TL;DR
Both unhealthy lifestyle and high genetic risk were independently associated with a higher risk of MCI.
JAMA Network Open · 17 authors, 7 centres
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Both unhealthy lifestyle and high genetic risk were independently associated with a higher risk of MCI.
Both unhealthy lifestyle and high genetic risk were independently associated with a higher risk of MCI. Unhealthy lifestyle was associated with higher MCI risk among participants with both low and high genetic risk. Significant synergistic interactions between genetic risk and lifestyle were observed, suggesting that an unhealthy lifestyle disproportionately amplifies MCI risk among those with high genetic susceptibility. Only 18.8% of participants met at least 4 of the 7 healthy diet criteria. Limitations include the observational design with potential unmeasured confounders, restriction to APOE ε4 and MTHFR as genetic markers, and reliance on questionnaire-based lifestyle data.