Association Studies on Gut and Lung Microbiomes in Patients with Lung Adenocarcinoma

Microorganisms · 8 authors, 6 centres

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TL;DR

The central finding was that specific gut bacterial species and metabolic pathways were associated with LADC development and progression, with the species Haemophilus parainfluenzae found in both the lung and gut of some patients.

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Key results included associations between increased gut abundances of specific species (e.g., Flavonifractor plautii, Eggerthella lenta, Clostridium innocuum, Clostridium aldenense) and cancer stage or metastasis. Haemophilus parainfluenzae was identified in both gut and lung microbiota of ten patients and had higher gut abundance in LADC patients. Associated metabolic pathways included leucine degradation, propanoyl-CoA catabolism, and fatty acid biosynthesis. The study suggests gut microbiota may influence LADC through immune responses and metabolites, but the design cannot establish causation. Limitations include the cross-sectional nature and the absence of identified taxa in BALF samples, implying an indirect mechanism.

STUDY TYPE

cross-sectional

SPECIALTY

oncology

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ORIGINAL PAPER

PMC10059697

Association Studies on Gut and Lung Microbiomes in Patients with Lung Adenocarcinoma

Microorganisms

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ABSTRACT

Abstract Lung adenocarcinoma (LADC) is a prevalent type of lung cancer that is associated with lung and gut microbiota. However, the interactions between these microbiota and cancer development remain unclear. In this study, a microbiome study was performed on paired fecal and bronchoalveolar lavage fluid (BALF) samples from 42 patients with LADC and 64 healthy controls using 16S rRNA gene amplicon and shotgun metagenome sequencing, aiming to correlate the lung and gut microbiota with LADC. Patients with LADC had reduced α-diversity in the gut microbiome and altered β-diversity compared with healthy controls, and the abundances of Flavonifractor , Eggerthella , and Clostridium were higher in the gut microbiome of LADC patients. The increased abundance of microbial species, such as Flavonifractor plautii , was associated with advanced-stage LADC and a higher metastasis rate. Phylogenetically, Haemophilus parainfluenzae was the most frequently shared taxon in the lung and gut microbiota of LADC patients. Gut microbiome functional pathways involving leucine, propanoate, and fatty acids were associated with LADC progression. In conclusion, the low diversity of the gut microbiota and the presence of H. parainfluenzae in gut and lung microbiota were linked to LADC development, while an increased abundance of F. plautii and the enriched metabolic pathways could be associated with the progression of LADC. Keywords: gut microbiome, lung microbiome, lung adenocarcinoma, gut–lung axis

CITATION EXPORT

Yaqiong Guo, Wenjie Yuan, Na Lyu et al.. Association Studies on Gut and Lung Microbiomes in Patients with Lung Adenocarcinoma. Microorganisms. (2023). https://doi.org/10.3390/microorganisms11030546

AUTHORS

8 · 6 CENTRES

Yaqiong Guo, Wenjie Yuan, Na Lyu, Yuanlong Pan, Xiaoqing Cao, Yuxuan Wang, Yi Han, Baoli Zhu

1CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
2University of Chinese Academy of Sciences, Beijing 100049, China
3Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China
4Beijing Chest Hospital, Capital Medical University, Beijing 101149, China
5Jinan Microecological Biomedicine Shandong Laboratory, Jinan 250117, China
6Department of Pathogenic Biology, School of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, China