Metabolomics · 9 authors, 3 centres
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This cross-sectional study used NMR metabolomics to analyze fasting plasma from 263 healthy Uzbek adults and found that higher sheep meat intake frequency was associated with lower levels of certain metabolites like pyruvate and phenylalanine, and higher levels of choline, after adjusting for confounders.
This cross-sectional population screening study applied a metabolomics approach using ^1^H NMR spectroscopy to investigate associations between sheep meat intake frequency (SMIF) and fasting blood plasma metabolites and lipoproteins in 263 healthy Uzbek adults. After statistical adjustment for nationality, sex, BMI, age, and intake frequency of total meat and fish, higher SMIF was significantly associated with lower levels of pyruvic acid, phenylalanine, ornithine, and acetic acid, and with an increasing trend in choline, asparagine, and dimethylglycine. The study found no significant association between SMIF and lipoprotein profiles (cholesterol, apoA1, LDL/HDL subfractions) after false discovery rate correction. Limitations include the cross-sectional design, lack of quantitative food intake data, and missing information on physical activity, which precludes causal inference. The findings suggest specific metabolic alterations linked to sheep meat consumption, warranting further longitudinal studies to establish causality.
