SEARCHCROSS-SECTIONALnutrition, epidemiology

cross-sectional·nutrition, epidemiology, public health, micronutrients, antioxidants·PMC10040542

Associations of dietary antioxidant micronutrients with the prevalence of obesity in adults

Frontiers in Nutrition · 8 authors, 3 centres

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This cross-sectional study analyzed NHANES data from 41,021 US adults aged 18 years or older spanning 2005 to 2018.

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This cross-sectional study analyzed NHANES data from 41,021 US adults aged 18 years or older spanning 2005 to 2018. Multivariate logistic regression, weighted quantile sum (WQS) regression, and restricted cubic spline (RCS) regression were used to examine associations between 11 dietary antioxidant micronutrients and the prevalence of obesity and abdominal obesity. The WQS index showed that the combination of 11 antioxidants was negatively associated with both obesity and abdominal obesity (all p<0.001), with iron and vitamin C carrying the greatest weights. Most individual antioxidants were inversely associated with obesity in logistic models, while selenium showed a positive association. RCS analysis revealed non-linear associations for eight nutrients with identifiable inflection points.

STUDY TYPE

cross-sectional

SPECIALTY

nutrition

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ORIGINAL PAPER

PMC10040542

Associations of dietary antioxidant micronutrients with the prevalence of obesity in adults

Frontiers in Nutrition

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ABSTRACT

Background Antioxidant micronutrients have a therapeutic potential for clinical treatment of obesity. NO research, however, has examined the connection between the complex level of dietary antioxidants and obesity. Materials and methods We mainly aimed to investigate the relationship between a combination of antioxidants and obesity using the database of the national health and nutrition examination survey (NHANES). This cross-sectional study contains a survey of 41,021 people (≥18 years) in total ranging from 2005 to 2018. Multivariate logistic and weighted quantile sum (WQS) regression were performed to investigate the associations between these antioxidants, both individually and collectively, and the prevalence of obesity. The restricted cubic spline (RCS) regression was also utilized to analyze the linearity of these associations. Results According to multivariate logistic models, we found that the levels of most antioxidants in the highest quartile were independently related to a lower prevalence of obesity, while a reverse result was observed in selenium ( p for trend <0.05). The WQS index revealed that a total of the 11 antioxidants is negatively related to the prevalence of obesity and abdominal obesity (all p <0.001), and iron/vitamin C have the greatest weight in the negative associations between antioxidant complex and obesity, as well as abdominal obesity. In addition, the RCS regression showed that retinol, vitamin A, α-carotene, β-carotene, β-cryptoxanthin, vitamin C, iron, and copper all had a non-linear association with obesity. Threshold effect analysis demonstrated that the inflection points of retinol, vitamin A, α-carotene, β-carotene, β-cryptoxanthin, vitamin C, iron, and cooper were 235.57, 374.81, 58.89, 891.44, 30.70, 43,410.00, 11,240.00, and 990.00 μg/day, respectively. Conclusion Our study found that a high level of a complex of 11 dietary antioxidants is related to a lower prevalence of obesity and abdominal obesity, among this inverse associations iron and vitamin C have the greatest weight.

CITATION EXPORT

Yazhu Yang, Haifeng Xu, Yi Zhang et al.. Associations of dietary antioxidant micronutrients with the prevalence of obesity in adults. Frontiers in Nutrition. (2023). https://doi.org/10.3389/fnut.2023.1098761

AUTHORS

8 · 3 CENTRES

Yazhu Yang, Haifeng Xu, Yi Zhang, Lin Chen, Chengzi Tian, Bihui Huang, Youpeng Chen, Lin Ma

1Department of Reproductive Medicine Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China
2Department of Infectious Diseases, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China
3Scientific Research Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China