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case-control·pediatrics, endocrinology, cardiology, epidemiology, public health·PMC10065857

Associations of Plasma BDNF and BDNF Gene Polymorphism with Cardiometabolic Parameters in Thai Children: A Pilot Study

Journal of Nutrition and Metabolism · 5 authors, 4 centres

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TL;DR

The BDNF G196A polymorphism was associated with decreased systolic blood pressure.

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This case-control study analyzed 469 Thai children (190 obese, 279 nonobese) to examine associations between plasma BDNF levels, two BDNF gene polymorphisms (G196A and C270T), and cardiometabolic parameters. Anthropometric, cardiometabolic, and hematological variables were measured, and genotyping was performed. The results showed no significant difference in BDNF levels between obese and nonobese groups. BDNF levels were positively correlated with systolic blood pressure, diastolic blood pressure, triglycerides, and the TyG index. The BDNF G196A polymorphism was associated with decreased systolic blood pressure, while the C270T polymorphism showed no significant associations. The study suggests that in Thai children, obesity is associated with cardiometabolic risk but not with BDNF levels or the studied polymorphisms, though G196A may be a marker for blood pressure control.

STUDY TYPE

case-control

SPECIALTY

pediatrics

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ORIGINAL PAPER

PMC10065857

Associations of Plasma BDNF and BDNF Gene Polymorphism with Cardiometabolic Parameters in Thai Children: A Pilot Study

Journal of Nutrition and Metabolism

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ABSTRACT

Abstract Background Childhood obesity is an important public health crisis worldwide. The brain-derived neurotrophic factor (BDNF) has been demonstrated to play a role in controlling energy homeostasis and cardiovascular regulation. Objectives To examine brain-derived neurotrophic factor (BDNF) levels and anthropometric-cardiometabolic and hematological parameters in obese and nonobese children and to determine whether two BDNF gene polymorphisms (G196A and C270T) are linked to BDNF levels, obesity, and anthropometric-cardiometabolic and hematological parameters among Thai children. Methods This case-control study included an analysis of 469 Thai children: 279 healthy nonobese and 190 obese children. Anthropometric-cardiometabolic and hematological variables and BDNF levels were measured. Genotyping of BDNF G196A and C270T was performed using the polymerase chain reaction-restriction fragment length polymorphism technique. Results Children in the obese group had significantly higher white blood cell counts and some cardiometabolic parameters. Although the difference in BDNF level between the nonobese and obese groups was not significant, BDNF level was significantly positively correlated with hematological and cardiometabolic parameters, including blood pressure, triglycerides, and triglycerides and the glucose index. The BDNF G196A polymorphism in children was only associated with decreased systolic blood pressure ( p < 0.05), while the BDNF C270T polymorphism was found not to be related to BDNF levels, obesity, or other parameters after adjusting for potential covariates. Conclusions These findings in Thai children suggest that obesity is associated with increased cardiometabolic risk factors, but not with BDNF levels or the two BDNF polymorphisms studied, while the BDNF G196A polymorphism is a beneficial marker for controlling blood pressure among Thai children.

CITATION EXPORT

Kanjana Suriyaprom, Banchamaphon Pheungruang, Somchai Pooudong et al.. Associations of Plasma BDNF and BDNF Gene Polymorphism with Cardiometabolic Parameters in Thai Children: A Pilot Study. Journal of Nutrition and Metabolism. (2023). https://doi.org/10.1155/2023/9668626

AUTHORS

5 · 4 CENTRES

Kanjana Suriyaprom, Banchamaphon Pheungruang, Somchai Pooudong, Pumpath Putpadungwipon, Chutima Sirikulchayanonta

1Faculty of Medical Technology, Rangsit University, Paholyothin Road, Pathumthani 12000, Thailand
2School of Nutrition and Dietetics, Institute of Public Health, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand
3Department of Tropical Nutrition and Food Science, Faculty of Tropical Medicine, Mahidol University, Rajvithi Road, Rajthevee, Bangkok 10400, Thailand
4College of Medicine, Rangsit University, Paholyothin Road, Pathumthani 12000, Thailand