Scientific Reports · 8 authors, 5 centres
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Using a rat model, this study found that supplementation with Astaxanthin and DHA in adulthood ameliorated proteomic signatures of adipose tissue dysfunction caused by perinatal undernutrition. The intervention reversed the upregulation of key proteins involved in lipogenesis and inflammation.
This preclinical study investigated the effect of adult Astaxanthin and DHA supplementation on adipose tissue dysfunction in rats exposed to perinatal undernutrition. Dams were fed 70% of their normal food intake. Perinatal undernutrition was confirmed by elevated hair cortisol and led to differential expression of proteins involved in adipogenesis, lipogenesis, and inflammation, such as FASN, AldoA, PKM2, and Ces1D. Supplementation with Astaxanthin and DHA downregulated these proteins, suggesting a protective modulation of metabolic pathways. Limitations include the preclinical rat model, potential protein degradation during extraction, and the lack of human clinical correlation. The findings provide mechanistic insight into how these supplements might counteract early-life nutritional stress on adipose tissue, but direct human relevance requires further validation.
