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TL;DR
The authors describe AD pathogenesis as involving impaired epidermal barrier function, altered immune response dominated by Th2 cells, microbial colonization—particularly Staphylococcus aureus—and psychological factors.
Life · 9 authors, 5 centres
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The authors describe AD pathogenesis as involving impaired epidermal barrier function, altered immune response dominated by Th2 cells, microbial colonization—particularly Staphylococcus aureus—and psychological factors.
The authors describe AD pathogenesis as involving impaired epidermal barrier function, altered immune response dominated by Th2 cells, microbial colonization—particularly Staphylococcus aureus—and psychological factors. Severity is assessed primarily using the EASI and SCORAD instruments. Treatment spans skincare and emollients, topical corticosteroids (the gold standard), topical immunomodulators, phototherapy, conventional systemic agents (cyclosporine, methotrexate, azathioprine), and newer interleukin inhibitors and JAK inhibitors. The review emphasizes that AD patients frequently have comorbidities and psychological burden, necessitating a multidisciplinary approach involving dermatologists, psychologists, pulmonologists, allergologists, nutritionists, and other specialists.