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TL;DR
In a mouse model of DSS-induced colitis, treatment with Bacteroides uniformis JCM5828 altered colonic microbiota and bile acid profiles, which was associated with the inhibition of TH17 cell differentiation and amelioration of colitis.
NPJ Biofilms and Microbiomes · 11 authors, 3 centres
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In a mouse model of DSS-induced colitis, treatment with Bacteroides uniformis JCM5828 altered colonic microbiota and bile acid profiles, which was associated with the inhibition of TH17 cell differentiation and amelioration of colitis.
This preclinical study used a DSS-induced colitis mouse model to investigate the effects of Bacteroides uniformis JCM5828 (Bu) on gut microbiota, bile acids, and inflammation. The authors report that Bu gavage changed the colonic microbial composition, suppressed pathogenic bacteria, and altered the bile acid profile, increasing key metabolites like α-MCA, HDCA, and isoLCA. These changes were associated with enhanced intestinal barrier function, reduced expression of pro-inflammatory cytokine genes, and inhibition of TH17 cell differentiation. The study also found that Bu suppressed phosphorylation of proteins in the NF-κB and MAPK inflammatory signaling pathways. The findings suggest a mechanism by which a probiotic bacterium can modulate host immunity through microbe-mediated bile acid metabolites.