Scientific Reports · 3 authors, 3 centres
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Using genome-wide association scans and metabolite profiling in genetically homogeneous inbred male Drosophila melanogaster reared under controlled conditions, the authors found that gut Basidiomycota abundance was negatively associated with host triglyceride and total fat metabolic pool levels, independent of glycogen and trehalose.
The study examined relationships between gut fungal and bacterial microbiota and energy storage metabolites (triglycerides, glycogen, trehalose) in genetically homogeneous inbred male Drosophila melanogaster reared under standardized diet, temperature, humidity, and density conditions. Using next-generation sequencing and genome-wide association scans, the authors found that Basidiomycota, the second most common but relatively rare fungal component, was negatively associated with triglyceride and total fat metabolic pool levels, independently of glycogen and trehalose. Ascomycota showed no significant correlation with any measured metabolites. Among bacteria, Acetobacter persici, Acetobacter pomorum, and Lactobacillus brevis were associated with lower fat metabolic pool. The authors identified host genes (fipi, Obp57c, ome) affecting both Basidiomycota and A. pomorum levels. Limitations include lack of species-level resolution for Basidiomycota and the correlational rather than interventional design.
