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TL;DR
It describes how neutrophil transmigration is a major contributor to early ALI and summarizes findings from various animal models (e.g., LPS administration, live bacteria) that have been used to study this process.
Critical Care · 2 authors, 2 centres
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It describes how neutrophil transmigration is a major contributor to early ALI and summarizes findings from various animal models (e.g., LPS administration, live bacteria) that have been used to study this process.
It describes how neutrophil transmigration is a major contributor to early ALI and summarizes findings from various animal models (e.g., LPS administration, live bacteria) that have been used to study this process. However, the authors emphasize major limitations, noting that these animal models do not replicate key clinical factors such as comorbidities, mechanical ventilation, and fluid management, making translation to human therapy difficult.