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systematic_review·nephrology, biomedical research, research methods, systematic review·PMC10287975

Bibliometric visualization analysis of gut-kidney axis from 2003 to 2022

Frontiers in Physiology · 8 authors, 4 centres

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This bibliometric study analyzed 3,900 publications on the gut-kidney axis using VOSviewer and R software, finding a significant increase in publications since 2011 and identifying immunity, inflammation, metabolism, and uremic toxins as the main research hotspots.

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The analysis showed a sharp increase in publications after the concept of the gut-kidney axis was introduced in 2011. The United States and China were identified as the leading countries, with the University of California, San Diego as the most active institution. Keyword clustering revealed four main research themes: immunity, inflammation, metabolism, and uremic toxins. Limitations include reliance on a single database, potential inclusion of loosely related literature, and citation bias favoring older papers. The study provides a quantitative overview of research trends and collaboration networks in the gut-kidney axis field.

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systematic_review

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nephrology

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ORIGINAL PAPER

PMC10287975

Bibliometric visualization analysis of gut-kidney axis from 2003 to 2022

Frontiers in Physiology

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ABSTRACT

Abstract Background: The gut-kidney axis refers to the interaction between the gastrointestinal tract and the kidneys, and its disorders have become increasingly important in the development of kidney diseases. The aim of this study is to identify current research hotspots in the field of the gut-kidney axis from 2003 to 2022 and provide guidance for future research in this field. Methods: We collected relevant literature on the gut-kidney axis from the Web of Science Core Collection (WoSCC) database and conducted bibliometric and visualization analyses using biblioshiny in R-Studio and VOSviewer (version 1.6.16). Results: A total of 3,900 documents were retrieved from the WoSCC database. The publications have shown rapid expansion since 2011, with the greatest research hotspot emerging due to the concept of the “intestinal-renal syndrome,” first proposed by Meijers. The most relevant journals were in the field of diet and metabolism, such as Nutrients. The United States and China were the most influential countries, and the most active institute was the University of California San Diego. Author analysis revealed that Denise Mafra, Nosratola D. Vaziri, Fouque, and Denis made great contributions in different aspects of the field. Clustering analysis of the keywords found that important research priorities were “immunity,” “inflammation,” “metabolism,” and “urinary toxin,” reflecting the basis of research in the field. Current research frontiers in the field include “hyperuricemia,” “gut microbiota,” “diabetes,” “trimethylamine n-oxide,” “iga nephropathy,” “acute kidney injury,” “chronic kidney disease,” “inflammation,” all of which necessitate further investigation. Conclusion: This study presents a comprehensive bibliometric analysis and offers an up-to-date outlook on the research related to the gut-kidney axis, with a specific emphasis on the present state of intercommunication between gut microbiota and kidney diseases in this field. This perspective may assist researchers in selecting appropriate journals and partners, and help to gain a deeper understanding of the field’s hotspots and frontiers, thereby promoting future research. Keywords: gut microbiota, kidney disease, gut-kidney axis, bibliometric analysis, VOSviewer

CITATION EXPORT

Sinan Ai, Yake Li, JiaYin Tao et al.. Bibliometric visualization analysis of gut-kidney axis from 2003 to 2022. Frontiers in Physiology. (2023). https://doi.org/10.3389/fphys.2023.1176894

AUTHORS

8 · 4 CENTRES

Sinan Ai, Yake Li, JiaYin Tao, Huijuan Zheng, Lei Tian, Yaoxian Wang, Zhen Wang, Wei Jing Liu

1 Renal Research Institution of Beijing University of Chinese Medicine, Beijing, China
2 Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China
3 Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China
4 Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, China