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other·preclinical research, biomedical research, endocrinology, pediatrics·PMC10635949

Binge drinking leads to an oxidative and metabolic imbalance in skeletal muscle during adolescence in rats: endocrine repercussion

Journal of Physiology and Biochemistry · 8 authors, 3 centres

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TL;DR

Adolescent rats exposed to a binge drinking ethanol model showed oxidative stress and disrupted energy and protein metabolism regulators in skeletal muscle, alongside altered serum myokine profiles. These findings suggest that adolescent binge drinking induces skeletal muscle damage with systemic endocrine consequences.

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BD exposure increased superoxide dismutase and catalase activities while decreasing glutathione peroxidase, resulting in elevated lipid and protein oxidation. Energy metabolism was disrupted through decreased total AMPKα expression but increased AMPK phosphorylation ratio, alongside reduced SREBP1. Protein turnover markers indicated a catabolic shift, with decreased pmTOR and increased FOXO3a, Atrogin-1/MAFBX, and ULK1.

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ORIGINAL PAPER

PMC10635949

Binge drinking leads to an oxidative and metabolic imbalance in skeletal muscle during adolescence in rats: endocrine repercussion

Journal of Physiology and Biochemistry

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ABSTRACT

Binge drinking (BD) is an especially pro-oxidant model of alcohol consumption, mainly used by adolescents. It has recently been related to the hepatic IR-process. Skeletal muscle is known to be involved in insulin action and modulation through myokine secretion. However, there is no information on muscle metabolism and myokine secretion after BD exposure in adolescents. Two experimental groups of adolescent rats have been used: control and BD-exposed one. Oxidative balance, energy status and lipid, and protein metabolism have been analyzed in muscle, together with myokine serum levels (IL-6, myostatin, LIF, IL-5, fractalkine, FGF21, irisin, BDNF, FSTL1, apelin, FABP3, osteocrin, osteonectin (SPARC), and oncostatin). In muscle, BD affects the antioxidant enzyme balance leading to lipid and protein oxidation. Besides, it also increases the activation of AMPK and thus contributes to decrease SREBP1 and pmTOR and to increase FOXO3a expressions, promoting lipid and protein degradation. These alterations deeply affect the myokine secretion pattern. This is the first study to examine a general myokine response after exposure to BD. BD not only caused a detrimental imbalance in myokines related to muscle turnover, decreased those contributing to increase IR-process, decreased FST-1 and apelin and their cardioprotective function but also reduced the neuroprotective BDNF. Consequently, BD leads to an important metabolic and energetic disequilibrium in skeletal muscle, which contributes to exacerbate a general IR-process. Supplementary Information The online version contains supplementary material available at 10.1007/s13105-023-00983-z.

CITATION EXPORT

Inés Romero-Herrera, Fátima Nogales, Javier Diaz-Castro et al.. Binge drinking leads to an oxidative and metabolic imbalance in skeletal muscle during adolescence in rats: endocrine repercussion. Journal of Physiology and Biochemistry. (2023). https://doi.org/10.1007/s13105-023-00983-z

AUTHORS

8 · 3 CENTRES

Inés Romero-Herrera, Fátima Nogales, Javier Diaz-Castro, Jorge Moreno-Fernandez, María del Carmen Gallego-Lopez, Julio J. Ochoa, Olimpia Carreras, María Luisa Ojeda

1https://ror.org/03yxnpp24grid.9224.d0000 0001 2168 1229Department of Physiology, Faculty of Pharmacy, Seville University, n° 2, 41012 Seville, Spain
2https://ror.org/04njjy449grid.4489.10000 0001 2167 8994Institute of Nutrition and Food Technology “José Mataix Verdú”, University of Granada, Avenida del Conocimiento s/n, 18071 Armilla, Granada Spain
3https://ror.org/04njjy449grid.4489.10000 0001 2167 8994Department of Physiology, University of Granada, Granada, Spain