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TL;DR
This narrative review summarizes how mechanical forces, such as fluid shear stress, regulate lymphatic vessel structure and function through mechanosensing and mechanotransduction pathways.
Cellular and Molecular Immunology · 2 authors, 2 centres
This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.
This narrative review summarizes how mechanical forces, such as fluid shear stress, regulate lymphatic vessel structure and function through mechanosensing and mechanotransduction pathways.
This narrative review examines the biomechanical control of lymphatic vessel physiology, focusing on how mechanical forces like fluid shear stress (FSS) influence lymphatic endothelial cells (LECs) and vessel behavior. The review also covers the plasticity of lymphatic vessels in response to inflammation and their roles in diseases such as lymphedema, inflammatory bowel disease, obesity, and cardiovascular disease. Implications suggest that understanding these mechanisms could lead to new therapeutic strategies targeting mechanical sensors like Piezo1 for lymphedema treatment.