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TL;DR
Using knockdown approaches and genome-wide chromatin binding analyses, the authors found that BMI1 modulates expression of more than four thousand genes in these cells.
Frontiers in Cell and Developmental Biology · 11 authors, 5 centres
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Using knockdown approaches and genome-wide chromatin binding analyses, the authors found that BMI1 modulates expression of more than four thousand genes in these cells.
Using knockdown approaches and genome-wide chromatin binding analyses, the authors found that BMI1 modulates expression of more than four thousand genes in these cells. BMI1 knockdown reduced self-renewal activity and induced cell cycle arrest and apoptosis. BMI1 was found to repress negative regulators of the PI3K-Akt pathway, including Tnc, Efna5, and Osmr, by depositing repressive histone modifications H2AK119ub1 and H3K27me3 at their loci. BMI1 also upregulated genes including Taf4 and Gdnf, which carry the active histone mark H3K27ac.