Bone Marrow Mesenchymal Stem-Cell-Derived Exosomes Ameliorate Deoxynivalenol-Induced Mice Liver Damage

Antioxidants · 8 authors, 3 centres

AI SUMMARY

FIDELITY 100%

This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.

AGENT 01 · STRUCTURED SUMMARY

TRACE TO SOURCE

“

TL;DR

This preclinical mouse study found that bone marrow mesenchymal stem cell-derived exosomes (BMSC-exos) reduced deoxynivalenol-induced liver damage by lowering lipid peroxidation markers, inflammatory cytokines, and maintaining liver function, with effects observed in a dose-dependent manner.

Full summary

739 CHARS

This preclinical study investigated the hepatoprotective effects of bone marrow mesenchymal stem cell-derived exosomes (BMSC-exos) against liver damage induced by the mycotoxin deoxynivalenol (DON) in mice. Central results showed that BMSC-exos decreased lipid peroxidation markers (MDA and 4-HNE), reduced inflammatory factors (IL-6 and TNF-α), and maintained liver function indicators (ALT and AST) in a dose-dependent manner. Comprehensive lipidomic and oxylipin profiling revealed that the exosomal lipid bilayer, rich in polyunsaturated fatty acids, preferentially reacted with free radicals, acting as a protective buffer. Cu/Zn SOD activity was significantly elevated after BMSC-exo treatment and correlated with screened oxylipins.

STUDY TYPE

other

SPECIALTY

preclinical research

SUMMARISED BY

AI pipeline

FIDELITY CHECK

100% · A

ORIGINAL PAPER

PMC10045494

Bone Marrow Mesenchymal Stem-Cell-Derived Exosomes Ameliorate Deoxynivalenol-Induced Mice Liver Damage

Antioxidants

READ THE FULL PAPER

ABSTRACT

Abstract Deoxynivalenol (DON) is a kind of Fusarium toxin that can cause a variety of toxic effects. DON is mainly metabolized and detoxified by the liver. When the concentration of DON exceeds the metabolic capacity of the liver, it will trigger acute or chronic damage to the liver tissue. Previous studies demonstrated that bone marrow mesenchymal stem-cell-secreted exosomes (BMSC-exos) reduce liver injury. Therefore, we issue a hypothesis that in vitro-cultured rat BMSC-secreted exos could ameliorate liver damage after 2 mg/kg bw/day of DON exposure. In total, 144 lipids were identified in BMEC-exos, including high polyunsaturated fatty acid (PUFA) levels. BMSC-exos treatment alleviated liver pathological changes and decreased levels of alanine aminotransferase, aspartate aminotransferase, inflammatory factors interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and lipid peroxidation. Otherwise, low or high BMSC-exos treatment obviously changes DON-induced hepatic oxylipin patterns. According to the results from our correlation network analysis, Pearson correlation coefficient analysis, and hierarchical clustering analysis, the top 10% oxidized lipids can be classified into two categories: one that was positively correlated with copper–zinc superoxide dismutase (Cu/Zn SOD) and another that was positively correlated with liver injury indicators. Altogether, BMSC-exos administration maintained normal liver function and reduced oxidative damage in liver tissue. Moreover, it could also significantly change the oxylipin profiles under DON conditions. Keywords: BMSC-exo, deoxynivalenol, oxidative stress, lipid peroxidation, oxylipin, hepatic damage

CITATION EXPORT

Zitong Meng, Yuxiao Liao, Zhao Peng et al.. Bone Marrow Mesenchymal Stem-Cell-Derived Exosomes Ameliorate Deoxynivalenol-Induced Mice Liver Damage. Antioxidants. (2023). https://doi.org/10.3390/antiox12030588

AUTHORS

8 · 3 CENTRES

Zitong Meng, Yuxiao Liao, Zhao Peng, Xiaolei Zhou, Huanhuan Zhou, Andreas K Nüssler, Liegang Liu, Wei Yang

1Hubei Key Laboratory of Food Nutrition and Safety, Department of Nutrition and Food Hygiene, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030, China
2MOE Key Lab of Environment and Health, Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030, China
3Department of Traumatology, BG Trauma Center, University of Tübingen, Schnarrenbergstr. 95, 72076 Tübingen, Germany