Journal of Bone Metabolism · 6 authors, 5 centres
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A retrospective cross-sectional study of 48 pediatric IBD patients assessed bone mineral density via DEXA scans and found a high prevalence of osteoporosis (27.1% total body, 39.5% spine) and osteopenia (33.3% total body, 32.6% spine), with low BMI, ileocolonic disease location, low calcium, low hemoglobin, and infliximab use as significant predictors.
This retrospective cross-sectional study evaluated BMD using DEXA of the total body and lumbar spine in 48 pediatric IBD patients (mean age at diagnosis 9.9±2.8 years; 62.5% male; 72.9% Crohn's disease). Osteoporosis was identified in 27.1% (total body) and 39.5% (spine) of patients, and osteopenia in 33.3% and 32.6%, respectively. On total body scans, osteoporosis was significantly associated with low BMI Z-score (P=0.038), ileocolonic disease location (P=0.008), and low calcium (P=0.008). On spinal scans, predictors included low BMI Z-score (P=0.039), low hemoglobin (P=0.018), low calcium (P=0.033), and infliximab use (P=0.019). One-way ANOVA showed significant differences in mean total body BMD Z-scores across the three disease locations (P=0.021), with small bowel involvement associated with lower scores than colonic disease (P=0.017). Limitations include the retrospective design, small sample size of 48, and exclusion of 103 of 152 registered patients who did not undergo BMD scanning.
