SEARCHOTHERobstetrics and gynecology, endocrinology

other·obstetrics and gynecology, endocrinology, neurology, nutrition, epidemiology·PMC10124253

Brain responses to food viewing in women during pregnancy and post partum and their relationship with metabolic health: study protocol for the FOODY Brain Study, a prospective observational study

BMJ Open · 10 authors, 10 centres

AI SUMMARY

FIDELITY 100%

POPULATIONPregnant women at 24–36 weeks gestational age and at 6 months post partum, with and without gestational diabetes mellitus (GDM).

INTERVENTIONObservation and measurement of brain responses (EEG to food images), eating behaviors, mood, stress, and metabolic health parameters.

COMPARISONWomen with GDM versus women without GDM.

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AGENT 01 · STRUCTURED SUMMARY

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TL;DR

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813 CHARS

The primary aim is to investigate spatiotemporal brain dynamics (via electroencephalography - EEG) in response to viewing food images of varying fat and carbohydrate content during pregnancy (24-36 weeks) and at 6 months postpartum. The central result will be the comparison of these brain responses between the two time points and between the GDM and non-GDM groups. Secondary outcomes include metabolic measures (weight, HbA1c, glucose, body composition), objective and subjective eating behaviors, depression, mood, and stress. The study is designed to link implicit brain responses to explicit measures of eating behavior and metabolic health to understand mechanistic pathways for excessive weight gain. The protocol aims to provide data for future interventions to manage weight gain and metabolic outcomes.

PICO

PPOPULATION

Pregnant women at 24–36 weeks gestational age and at 6 months post partum, with and without gestational diabetes mellitus (GDM).

IINTERVENTION

Observation and measurement of brain responses (EEG to food images), eating behaviors, mood, stress, and metabolic health parameters.

OOUTCOME

Primary: Brain responses (amplitude, latency, topography, source estimation) to food images of varying fat/carbohydrate content. Secondary: Weight, HbA1c, glucose measures, body composition, eating rate, eating behaviors, depression, mood, stress.

STUDY TYPE

other

SPECIALTY

obstetrics and gynecology

SUMMARISED BY

AI pipeline

FIDELITY CHECK

100% · A

ORIGINAL PAPER

PMC10124253

Brain responses to food viewing in women during pregnancy and post partum and their relationship with metabolic health: study protocol for the FOODY Brain Study, a prospective observational study

BMJ Open

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ABSTRACT

Abstract Introduction Food cravings are common in pregnancy and along with emotional eating and eating in the absence of hunger, they are associated with excessive weight gain and adverse effects on metabolic health including gestational diabetes mellitus (GDM). Women with GDM also show poorer mental health, which further can contribute to dysregulated eating behaviour. Food cravings can lead to greater activity in brain centres known to be involved in food ‘wanting’ and reward valuation as well as emotional eating. They are also related to gestational weight gain. Thus, there is a great need to link implicit brain responses to food with explicit measures of food intake behaviour, especially in the perinatal period. The aim of this study is to investigate the spatiotemporal brain dynamics to visual presentations of food in women during pregnancy and in the post partum, and link these brain responses to the eating behaviour and metabolic health outcomes in women with and without GDM. Methods and analysis This prospective observational study will include 20 women with and 20 without GDM, that have valid data for the primary outcomes. Data will be assessed at 24–36 weeks gestational age and at 6 months post partum. The primary outcomes are brain responses to food pictures of varying carbohydrate and fat content during pregnancy and in the post partum using electroencephalography. Secondary outcomes including depressive symptoms, current mood and eating behaviours will be assessed with questionnaires, objective eating behaviours will be measured using Auracle and stress will be measured with heart rate and heart rate variability (Actiheart). Other secondary outcome measures include body composition and glycaemic control parameters. Ethics and dissemination The Human Research Ethics Committee of the Canton de Vaud approved the study protocol (2021-01976). Study results will be presented at public and scientific conferences and in peer-reviewed journals. Keywords: Diabetes in pregnancy, Neurobiology, NUTRITION & DIETETICS, Eating disorders

CITATION EXPORT

Anna Lesniara-Stachon, Dan Yedu Quansah, Sybille Schenk et al.. Brain responses to food viewing in women during pregnancy and post partum and their relationship with metabolic health: study protocol for the FOODY Brain Study, a prospective observational study. BMJ Open. (2023). https://doi.org/10.1136/bmjopen-2022-067013

AUTHORS

10 · 10 CENTRES

Anna Lesniara-Stachon, Dan Yedu Quansah, Sybille Schenk, Chrysa Retsa, Ryan J Halter, Micah M Murray, Alain Lacroix, Antje Horsch, Ulrike Toepel, Jardena J Puder

1Obstetric Service, Department Woman-Mother-Child, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
2Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland
3Service of Endocrinology, Diabetes and Metabolism, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
4Laboratory for Investigative Neurophysiology (the LINE), Radiology Department, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
5The Sense Innovation and Research Center, Lausanne and Sion, Switzerland
6CIBM Center for Biomedical Imaging, Lausanne, Switzerland
7Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA
8Department of Surgery, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, USA
9Institute of Higher Education and Research in Healthcare (IUFRS), University of Lausanne, Lausanne, Switzerland
10Neonatology service, Department Woman-Mother-Child, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland