Polymers · 5 authors, 4 centres
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This narrative review synthesizes preclinical and clinical literature from 2017 to 2022 on polymeric nano-based drug-delivery systems for ocular diseases. The central conclusion is that these nanocarrier systems can penetrate ocular anatomical barriers, improve drug bioavailability, extend tissue residence time, and offer biodegradable alternatives to conventional topical formulations.
This narrative review by Wu et al. surveys preclinical and clinical studies published between 2017 and 2022 on polymeric nano-based drug-delivery systems (DDS) for anterior segment diseases and glaucoma. The authors describe how the eye's anatomical barriers severely limit the bioavailability and residence time of topically administered drugs. They analyze how different biopolymers, including cellulose derivatives and mucoadhesive polymers, can be incorporated into nanocarriers to increase retention time, enhance membrane permeability, and enable targeted or stimulus-responsive delivery. The review identifies improved patient compliance through reduced administration frequency as a potential clinical benefit. The authors suggest polymeric nano-based DDS represent a promising but still evolving therapeutic approach requiring further research.
