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other·oncology, pulmonology, preclinical research, biomedical research·PMC10891399

Bronchoscopic deployment and implantation of Diffusing alpha-emitters Radiation Therapy into the lung and mediastinum for treatment of lung cancer: a pre-clinical safety and feasibility study

Translational Lung Cancer Research · 11 authors, 4 centres

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TL;DR

This pre-clinical study evaluated the feasibility and safety of deploying Alpha DaRT radiation sources via bronchoscopy into the lung and mediastinum of healthy swine. The study found the bronchoscopic deployment was feasible, precise, and safe, with no adverse events or significant complications observed.

Full summary

802 CHARS

The study investigated the feasibility, usability, and safety of bronchoscopic deployment of Alpha DaRT radiation sources into the lung parenchyma and mediastinum in a healthy swine model. The procedure was performed in two phases: inert and active Alpha DaRTs. A total of 158 sources were successfully inserted in five swine. Deployment in clusters separated by approximately 4 mm was achievable. No adverse events or clinically significant abnormalities were observed in health monitoring or hematologic evaluation. Histopathology showed local mild inflammatory changes, minimal fibrosis, and dystrophic mineralization with giant cells. Serial CT imaging showed minimal source movement and no migration. The study supports the potential translation of this technique for future lung cancer treatment.

STUDY TYPE

other

SPECIALTY

oncology

SUMMARISED BY

AI pipeline

FIDELITY CHECK

100% · A

ORIGINAL PAPER

PMC10891399

Bronchoscopic deployment and implantation of Diffusing alpha-emitters Radiation Therapy into the lung and mediastinum for treatment of lung cancer: a pre-clinical safety and feasibility study

Translational Lung Cancer Research

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ABSTRACT

Background Radiotherapy is a standard treatment modality in cancer therapy, particularly for lung cancer. Diffusing alpha-emitters Radiation Therapy sources (hereafter, “Alpha DaRTs”) are fixed with Ra-244 (half-life =3.6 days) that releases alpha-emitting atoms into the tumor tissue to an effective range of a few millimeters. Methods The feasibility, usability, and safety of Alpha DaRTs deployment and implantation via bronchoscopy into the lung parenchyma and mediastinum in a big animal model of healthy swine was studied in two phases: (I) inert and (II) active Alpha DaRTs deployment. The Alpha DaRTs were inserted in both individual and cluster patterns based on a predefined plan. Swine health was monitored throughout the study. The usability of bronchoscopic deployment and implantation was evaluated using a user questionnaire. The movement and migration of the Alpha DaRTs were assessed. Necropsy was performed, and lungs were evaluated via gross pathology and histopathology. Results A total of 158 Alpha DaRTs were inserted successfully in the lung parenchyma and mediastinum of five swine in two phases. It was possible to deliver and place the Alpha DaRTs in clusters of no more than 4 mm distance between the Alpha DaRTs. No adverse event or change in the health and general condition of animals was observed. Hematologic evaluation did not show any clinically significant abnormality related to the Alpha DaRTs. Histopathology demonstrated local mild inflammatory changes, minimal fibrosis, and dystrophic mineralization with giant cells. Minimal movement and no migration of Alpha DaRTs were observed. Conclusions Bronchoscopic deployment of Alpha DaRTs in the lung parenchyma and mediastinum of the porcine animal is feasible, precise, and safe.

CITATION EXPORT

Ali Sadoughi, Abhishek Sarkar, Carol Novotney et al.. Bronchoscopic deployment and implantation of Diffusing alpha-emitters Radiation Therapy into the lung and mediastinum for treatment of lung cancer: a pre-clinical safety and feasibility study. Translational Lung Cancer Research. (2024). https://doi.org/10.21037/tlcr-23-639

AUTHORS

11 · 4 CENTRES

Ali Sadoughi, Abhishek Sarkar, Carol Novotney, Christine Chan, Gerardo Moreno, Stephanie Oren, Lior Moss, Kobi Aharoni, Saleem Eben Bari, Nir Edery, Nitin Ohri

1Department of Medicine, Division of Pulmonology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA;
2Department of Medicine, Division of Pulmonary and Critical Care Medicine, Westchester Medical Center, Valhalla, NY, USA;
3Center for Animal Resources and Education (C.A.R.E.), Montefiore Medical Center, Bronx, NY, USA;
4Department of Pathology, Kimron Veterinary Institute, Bet Dagan, Israel; 5Department of Radiation Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA