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other·preclinical research, biomedical research, nutrition, endocrinology·PMC10037069

Calebin-A prevents HFD-induced obesity in mice by promoting thermogenesis and modulating gut microbiota

Journal of Traditional and Complementary Medicine · 6 authors, 6 centres

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TL;DR

This preclinical mouse study investigated the effects of calebin A on diet-induced obesity. It found that calebin A reduced weight gain and blood sugar, improved thermogenesis, and altered gut microbiota composition in mice fed a high-fat diet.

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This preclinical study used C57BL/6J mice to investigate the anti-obesity effects of calebin A. The study assessed body weight, blood glucose, adipose tissue weights (white, beige, brown), liver weight, rectal temperature during cold exposure, and gut microbiota composition via 16S rRNA sequencing. Results showed that calebin A treatment dose-dependently reduced HFD-induced weight gain and blood glucose levels. It also decreased the weight of various adipose tissues and restored liver weight. In cold exposure tests, calebin A-treated mice maintained higher rectal temperatures, suggesting enhanced thermogenesis. Gut microbiota analysis revealed enrichment of specific commensal bacteria, including *Akkermansia*.

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other

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preclinical research

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ORIGINAL PAPER

PMC10037069

Calebin-A prevents HFD-induced obesity in mice by promoting thermogenesis and modulating gut microbiota

Journal of Traditional and Complementary Medicine

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ABSTRACT

Background and aim Obesity is one of the complications of sedentary lifestyle and high-calorie food intake which become a global problem. Thermogenesis is a novel way to promote anti-obesity by consuming energy as heat rather than storing it as triacylglycerols. Over the last decade, growing evidence has identified the gut microbiota as a potential factor in the pathophysiology of obesity. Calebin A is a non-curcuminoid novel compound derived from the rhizome of medicinal turmeric with putative anti-obesity effects. However, its ability on promoting thermogenesis and modulating gut microbiota remain unclear. Experimental procedure C57BL/6J mice were fed either normal diet or high-fat diet (HFD) supplement with calebin A (0.1 and 0.5%) diet for 12 weeks. The composition of the gut microbiota was assessed by analyzing 16S rRNA gene sequences. Results and conclusion Mice treated with calebin A shows a remarkable alteration in microbiota composition compared with that of normal diet-fed or HFD-fed mice and is characterized by an enrichment of Akkermansia , Butyricicoccus , Ruminiclostridium_9 , and unidentified_Ruminococcaceae . We also explored that calebin A reduce the weight and blood sugar of mice that are induced by HFD, and show a dose-dependent reaction. Moreover, calebin A decreases the weight of white, beige, and brown adipose tissue, and also restores liver weight. In cold exposure experiments, calebin A can better maintain rectal temperature through thermogenesis. In summary, calebin A has a good thermogenesis function and is effective in anti-obesity. It can be used as a novel gut microbiota modulator to prevent HFD-induced obesity.

CITATION EXPORT

Pei-Sheng Lee, Ying-Ying Lu, Kalyanam Nagabhushanam et al.. Calebin-A prevents HFD-induced obesity in mice by promoting thermogenesis and modulating gut microbiota. Journal of Traditional and Complementary Medicine. (2023). https://doi.org/10.1016/j.jtcme.2022.01.001

AUTHORS

6 · 6 CENTRES

Pei-Sheng Lee, Ying-Ying Lu, Kalyanam Nagabhushanam, Chi-Tang Ho, Hui-Ching Mei, Min-Hsiung Pan

aInstitute of Food Science and Technology, National Taiwan University, Taipei, 10617, Taiwan
bDepartment of Natural Science Education, National Taipei University of Education, Taipei, Taiwan
cSabinsa Corporation, East Windsor, NJ, 08520, USA
dDepartment of Food Science, Rutgers University, New Brunswick, NJ, 08901, USA
eDepartment of Medical Research, China Medical University Hospital, China Medical University, Taichung, 40402, Taiwan
fDepartment of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan