SEARCHSYSTEMATIC_REVIEWpsychiatry, epidemiology

systematic_review·psychiatry, epidemiology, systematic review, public health, biomedical research·PMC10617739

Candidate gene-environment interactions in substance abuse: A systematic review

PLOS ONE · 3 authors, 3 centres

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TL;DR

This systematic review of 44 studies found that 38 reported at least one significant gene-environment interaction for substance use, with the diathesis–stress model being the most common pattern.

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116 CHARS

The authors tabulated study demographics and key findings, coding interaction patterns into four theoretical models.

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systematic_review

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psychiatry

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AI pipeline

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ORIGINAL PAPER

PMC10617739

Candidate gene-environment interactions in substance abuse: A systematic review

PLOS ONE

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ABSTRACT

Abstract Background The abuse of psychogenic drugs can lead to multiple health-related problems. Genetic and environmental vulnerabilities are factors in the emergence of substance use disorders. Empirical evidence regarding the gene–environment interaction in substance use is mixed. Summaries of the latest findings from a candidate gene approach will be useful for revealing the significance of particular gene contributions. Thus, we aim to identify different gene–environment interactions in patterns of substance use and investigate whether any effects trend notably across different genders and races. Methods We reviewed published studies, until March 1, 2022, on substance use for candidate gene–environment interaction. Basic demographics of the included studies, target genes, environmental factors, main findings, patterns of gene–environment interaction, and other relevant information were collected and summarized. Results Among a total of 44 studies, 38 demonstrated at least one significant interaction effect. About 61.5% of studies on the 5-HTTLPR gene, 100% on the MAOA gene, 42.9% on the DRD2 gene, 50% on the DRD4 gene, 50% on the DAT gene, 80% on the CRHR1 gene, 100% on the OPRM1 gene, 100% on the GABRA1 gene, and 50% on the CHRNA gene had a significant gene–environment interaction effect. The diathesis–stress model represents a dominant interaction pattern (89.5%) in the studies with a significant interaction effect; the remaining significant effect on substance use is found in the differential susceptibility model. The social push and swing model were not reported in the included studies. Conclusion The gene–environment interaction research on substance use behavior is methodologically multidimensional, which causes difficulty in conducting pooled analysis, or stated differently–making it hard to identify single sources of significant influence over maladaptive patterns of drug taking. In decreasing the heterogeneity and facilitating future pooled analysis, researchers must (1) replicate the existing studies with consistent study designs and measures, (2) conduct power calculations to report gene–environment correlations, (3) control for covariates, and (4) generate theory-based hypotheses with factorial based experiments when designing future studies.

CITATION EXPORT

Zheng Jiang, Zidong Chen, Xi Chen. Candidate gene-environment interactions in substance abuse: A systematic review. PLOS ONE. (2023). https://doi.org/10.1371/journal.pone.0287446

AUTHORS

3 · 3 CENTRES

Zheng Jiang, Zidong Chen, Xi Chen

1Jockey Club School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Hong Kong
2Department of Sociology and Social Policy, Lingnan University, Tuen Mun, Hong Kong
3University of Wisconsin-Green Bay, UNITED STATES