SEARCHCOHORTepidemiology, gastroenterology

cohort·epidemiology, gastroenterology, endocrinology, public health, observational study·PMC10633920

Cardiometabolic Index (CMI), Lipid Accumulation Products (LAP), Waist Triglyceride Index (WTI) and the risk of acute pancreatitis: a prospective study in adults of North China

Lipids in Health and Disease · 7 authors, 4 centres

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TL;DR

Over a median follow-up of 12.59±0.98 years, 401 AP cases were documented.

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Over a median follow-up of 12.59±0.98 years, 401 AP cases were documented. After adjusting for confounders, the highest quartiles of CMI, LAP, and WTI were all significantly associated with increased AP risk, with hazard ratios ranging from 1.93 to 2.13 compared to the lowest quartiles. Obesity (BMI≥28 kg/m²) was also associated with increased AP risk (HR=1.58). The study found that combining CMI with BMI improved prognostic value for AP compared to BMI alone. Limitations include the study's restriction to a Chinese population, potential residual confounding, and the homogeneous lifestyle of participants from a single urban area.

STUDY TYPE

cohort

SPECIALTY

epidemiology

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AI pipeline

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100% · A

ORIGINAL PAPER

PMC10633920

Cardiometabolic Index (CMI), Lipid Accumulation Products (LAP), Waist Triglyceride Index (WTI) and the risk of acute pancreatitis: a prospective study in adults of North China

Lipids in Health and Disease

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ABSTRACT

Abstract Objective To investigate the correlation between anthropometric indexes [cardiometabolic index (CMI), lipid accumulation products (LAP), waist triglyceride index (WTI), and body mass index (BMI)] and acute pancreatitis (AP) in a Chinese adult population. Methodology The present investigation consisted of a prospective group including 117,326 subjects who were enrolled in the Kailuan investigation. The individuals were categorized into quartiles based on their baseline levels of CMI, LAP, and WIT. BMI was categorized into three distinctive groups: normal weight group (BMI < 24 kg/m 2 ), overweight group (BMI 24–28 kg /m 2 ), and obesity group (BMI ≥ 28 kg/m 2 ). The data were subjected to analysis in order to investigate the correlation between these anthropometric indexes and the incidence of AP. Cox regression models were employed to assess the relative risk of AP while accounting for known risk factors through appropriate adjustments. Outcomes Over the course of a median follow-up duration of 12.59 ± 0.98 years, we documented 401 incident AP cases. Incidence density and cumulative incidence rates of AP increased with the increase of CMI, LAP, and WTI. After multivariate adjustment, the fourth quartile of CMI, LAP, and WTI exhibited the greatest risk of AP [CMI: hazard ratio (HR) 1.93, 95% confidential interval (CI) (1.45–2.57); LAP: HR 2.00, 95% CI(1.49–2.68); WTI: HR 2.13,95% CI (1.59–2.83)]. In comparison to the normal weight group, the obesity group (BMI ≥ 28 kg/m 2 ) had an elevated risk of AP (HR = 1.58, 95% CI: 1.21–2.05). Furthermore, the incremental effect of BMI combined with CMI on the prognostic value of AP was greater than that of BMI alone (the C statistics demonstrated a result of 0.607 versus 0.546; the integrated discrimination improvement revealed a result of 0.321%; net reclassification improvement was 1.975%). Conclusion We found that CMI, LAP, and WTI were positively and independently connected to the risk of AP. Additionally, CMI demonstrates a superior prognostic capacity than other indexes in anticipating AP. Supplementary Information The online version contains supplementary material available at 10.1186/s12944-023-01948-3. Keywords: Acute pancreatitis, Anthropometry visceral adiposity index, Cardiometabolic index, Lipid accumulation products, Waist triglyceride index, Prospective cohort study

CITATION EXPORT

Qiu Sun, Qingshuai Ren, Liming Du et al.. Cardiometabolic Index (CMI), Lipid Accumulation Products (LAP), Waist Triglyceride Index (WTI) and the risk of acute pancreatitis: a prospective study in adults of North China. Lipids in Health and Disease. (2023). https://doi.org/10.1186/s12944-023-01948-3

AUTHORS

7 · 4 CENTRES

Qiu Sun, Qingshuai Ren, Liming Du, Shuohua Chen, Shouling Wu, Bing Zhang, Bangmao Wang

1Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Tianjin Institute of Digestive Diseases, Tianjin Key Laboratory of Digestive Diseases, 154 Anshan Road, Heping District, Tianjin, 300052 China
2Department of Hepatobiliary, Kailuan General Hospital, No.57 Xinhua East Street, Tangshan, 063000 China
3Deparment of Cardiovascular Surgery, North China University of Science and Technology, Tangshan, 063000 China
4Department of Cardiology, Kailuan General Hospital, North China University of Science and Technology, No.57 Xinhua East Street, Tangshan, 063000 China