other·epidemiology, gastroenterology, public health, observational study, biomedical research·PMC10587414
Causal association between adiposity and hemorrhoids: a Mendelian randomization study
Frontiers in Medicine · 4 authors, 3 centres
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The authors applied univariable IVW MR as the primary analysis, with maximum likelihood, weighted median, MR-PRESSO, and MR-Egger as sensitivity analyses, plus multivariable MR adjusting for physical activity.
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The authors applied univariable IVW MR as the primary analysis, with maximum likelihood, weighted median, MR-PRESSO, and MR-Egger as sensitivity analyses, plus multivariable MR adjusting for physical activity. For each 1-SD increase in genetically determined adiposity, IVW MR showed BMI OR=1.005 (95% CI 1.003-1.008, p=7.801×10⁻⁵), waist circumference OR=1.008 (95% CI 1.005-1.011, p=1.051×10⁻⁶), and nominally significant associations for body fat percentage and waist-to-hip ratio.
