Genes · 2 authors, 2 centres
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A two-sample Mendelian randomisation study using GWAS summary statistics found a causal association between iritis and glaucoma in both East Asian and multi-ethnic populations, and between uveitis and glaucoma in the multi-ethnic population only, with limited power in the East Asian population.
This two-sample Mendelian randomisation study used GWAS summary statistics from East Asian and multi-ethnic cohorts to investigate causal associations between iritis or uveitis and glaucoma. The authors found a causal association between iritis and glaucoma in both the East Asian and multi-ethnic populations. Uveitis showed a causal association with glaucoma in the multi-ethnic population, though power constraints in the East Asian analysis limited detection. Key SNPs were concentrated on chromosome 6 near HLA loci. The authors note that uveitis-related SNPs are rare and HLA-associated, which is not ideal for MR, but argue the significance of results despite these limitations supports a very strong association.
