Cell-Tissue Interaction: The Biomimetic Approach to Design Tissue Engineered Biomaterials

Bioengineering · 6 authors, 1 centre

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TL;DR

This narrative review synthesizes current knowledge on designing tissue-engineered biomaterials using a biomimetic approach.

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This narrative review synthesizes current knowledge on designing tissue-engineered biomaterials using a biomimetic approach. A central theme is the potential for Universal Cell-biomaterial Parameters (UCPs) to standardize and simplify the understanding of these interactions.

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narrative_review

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preclinical research

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ORIGINAL PAPER

PMC10604880

Cell-Tissue Interaction: The Biomimetic Approach to Design Tissue Engineered Biomaterials

Bioengineering

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ABSTRACT

Abstract The advancement achieved in Tissue Engineering is based on a careful and in-depth study of cell–tissue interactions. The choice of a specific biomaterial in Tissue Engineering is fundamental, as it represents an interface for adherent cells in the creation of a microenvironment suitable for cell growth and differentiation. The knowledge of the biochemical and biophysical properties of the extracellular matrix is a useful tool for the optimization of polymeric scaffolds. This review aims to analyse the chemical, physical, and biological parameters on which are possible to act in Tissue Engineering for the optimization of polymeric scaffolds and the most recent progress presented in this field, including the novelty in the modification of the scaffolds’ bulk and surface from a chemical and physical point of view to improve cell–biomaterial interaction. Moreover, we underline how understanding the impact of scaffolds on cell fate is of paramount importance for the successful advancement of Tissue Engineering. Finally, we conclude by reporting the future perspectives in this field in continuous development. Keywords: extracellular matrix, cell-tissue interactions, tissue engineering, regenerative medicine, scaffolds

CITATION EXPORT

Paola Nitti, Athira Narayanan, Rebecca Pellegrino et al.. Cell-Tissue Interaction: The Biomimetic Approach to Design Tissue Engineered Biomaterials. Bioengineering. (2023). https://doi.org/10.3390/bioengineering10101122

AUTHORS

6 · 1 CENTRES

Paola Nitti, Athira Narayanan, Rebecca Pellegrino, Stefania Villani, Marta Madaghiele, Christian Demitri

1Department of Engineering for Innovation, University of Salento, 73100 Lecce, Italy; [email protected] (A.N.); [email protected] (R.P.); [email protected] (S.V.); [email protected] (M.M.); [email protected] (C.D.)