Frontiers in Neuroscience · 3 authors, 3 centres
This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.
This narrative review compiles single-cell RNA sequencing studies describing the diversity of cell types—including neurons, glial cells, immune cells, and vascular cells—within the peripheral nervous system. It highlights how single-cell approaches reveal cellular heterogeneity across developmental, regenerative, and disease states, while noting that multi-omics applications in the PNS remain limited compared to the CNS.
This narrative review synthesizes published single-cell RNA sequencing studies characterizing cellular diversity in the peripheral nervous system (PNS). Sub-types of neurons and glial cells have been recognized in tissues under different physiological and pathological states. The review notes that different tissues exhibit different cell types or markers, potentially due to variation in sequencing technology or analysis methods, and suggests combining bulk-seq, high-throughput sequencing, and deep sequencing to reduce this variation. The authors observe that single-cell multi-omics has mainly focused on the CNS, with relatively limited application in the PNS, and call for broader adoption of these technologies to support identification of therapeutic targets for nerve injuries.
