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TL;DR
This narrative review examines the senescence characteristics of mesenchymal stem cells (MSCs) and the microenvironmental factors that regulate this process.
Frontiers in Cell and Developmental Biology · 4 authors, 1 centre
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This narrative review examines the senescence characteristics of mesenchymal stem cells (MSCs) and the microenvironmental factors that regulate this process.
This narrative review examines the senescence characteristics of mesenchymal stem cells (MSCs) and the microenvironmental factors that regulate this process. A significant limitation noted is that most animal experiments with MSCs have focused on only a single disease model, whereas clinical patients often suffer from multiple diseases. The authors also note that up to now, MSCs have been the subject of more than 1,599 clinical trials, yet only two involve pretreatment.