Drug Metabolism and Disposition · 1 author, 1 centre
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This narrative review describes the roles of cytochrome P450 enzymes in ocular tissues under normal and pathological conditions and identifies barriers to studying them in the eye. It highlights the need for interdisciplinary collaboration between P450 researchers and ophthalmology experts to advance understanding of P450 functions in vision and blindness.
The review identifies several barriers to P450 ocular research, including the complexity of eye anatomy, the need for specialized characterization techniques, difficulty in obtaining fresh human eye tissues through eye banks, and the small size of mouse eyes requiring large colonies. It emphasizes that only very few P450 laboratories have expanded research to the eye. The author recommends practical entry points such as immunolocalization of P450s in human and mouse ocular tissues, ocular phenotyping of systemic or cell-specific P450 knockout mice, and leveraging NEI-supported P30 Core facilities for ophthalmology equipment access.
