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TL;DR
The central suggestion is that HVR may reduce individual variability and improve diagnostic accuracy.
Brain and Behavior · 3 authors, 1 centre
This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.
The central suggestion is that HVR may reduce individual variability and improve diagnostic accuracy.
They discuss the high cost and burden of micro-biomarkers and the large population variation in hippocampal volume (HV), which undermines its validity. As a solution, the authors propose the hippocampal-to-ventricle ratio (HVR), arguing it may be a more reliable marker of structural integrity by accounting for both gray matter atrophy and adjacent ventricular expansion. They note emerging evidence that HVR predicts memory functions better than HV alone in an elderly sample. The paper concludes that HVR is a promising but preliminary marker requiring further validation in clinical studies with mild cognitive impairment (MCI) and AD patients, and in longitudinal studies to test its predictive power for conversion from normal to MCI/AD.