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TL;DR
In a randomized controlled trial of 100 healthy adults, males informed of low genetic risk for elevated BMI and lipids showed significant decreases in anxiety and depression and increased meat intake at 3 months compared to baseline.
PLOS ONE · 10 authors, 5 centres
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In a randomized controlled trial of 100 healthy adults, males informed of low genetic risk for elevated BMI and lipids showed significant decreases in anxiety and depression and increased meat intake at 3 months compared to baseline.
In this randomized controlled trial, 100 healthy adults were assigned to an intervention group receiving polygenic risk information for BMI and lipid profiles or a not-informed control group. Intervention participants were subclassified by perceived risk level into low (ILR, n=32) and high (IHR, n=33) risk subgroups. Dietary intake was assessed via 3-day dietary records, and anxiety and depression were measured using GAD-7 and PHQ-9 at baseline, 3 months, and 6 months. Male subjects in the ILR group showed a significant increase in protein and meat intake at 3 months compared to baseline, with meat intake change of 49.4 ± 30.8 g/d. Anxiety levels significantly decreased at 3 months in the ILR group, and anxiety scores were negatively associated with meat intake (standardized β = -0.321). Depression levels decreased at both 3 and 6 months in the ILR group. Meat intake at 3 months was associated with blood arginine and ornithine levels. No significant changes were observed in the IHR or control groups, or among female subjects.