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case_report·pediatrics, gastroenterology, oncology, hematology, infectious disease·PMC10191500

Child With Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue

JPGN Reports · 3 authors, 2 centres

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TL;DR

This is a case report of a 9-year-old girl diagnosed with gastric MALT lymphoma associated with H. pylori infection, found via endoscopy for abdominal pain. After H. pylori eradication failed to shrink the tumor, chemotherapy achieved complete remission.

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This case report describes a 9-year-old girl who presented with a 3-month history of severe abdominal pain, weight loss, and black stools. The patient was treated with H. pylori eradication therapy, but the mass showed no change. She then received 6 cycles of chemotherapy, which led to complete remission confirmed by follow-up endoscopy. The report highlights the rarity of this condition in children and the importance of endoscopy for diagnosis, noting that while H. pylori eradication alone can treat early-stage disease, advanced cases may require chemotherapy.

STUDY TYPE

case_report

SPECIALTY

pediatrics

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AI pipeline

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100% · A

ORIGINAL PAPER

PMC10191500

Child With Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue

JPGN Reports

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ABSTRACT

Many patients present to our clinic with Helicobacter pylori ( H. pylori ) infection. Most have nonspecific symptoms that cannot be immediately attributed to H. pylori . The joint European Society for Paediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN)/North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN) guidelines recommend upper gastroscopy to detect the cause of such symptoms. Herein, we present the case of a 9-year-old girl diagnosed with gastric mucosa-associated lymphoid tissue lymphoma associated with H. pylori infection using upper gastroscopy. We believe that a patient of such a young age with this serious condition secondary to H. pylori will highlight the importance of upper gastrointestinal endoscopy in such cases.

CITATION EXPORT

Khalid A. Alghamdi, Alaa M. Bokhari, Imad A. El Hag. Child With Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue. JPGN Reports. (2021). https://doi.org/10.1097/PG9.0000000000000120

AUTHORS

3 · 2 CENTRES

Khalid A. Alghamdi, Alaa M. Bokhari, Imad A. El Hag

From the *Pediatric Department, Security Forces Hospital, Riyadh, Saudi Arabia
†Histopathology Department, Security Forces Hospital, Riyadh, Saudi Arabia.