Childhood and Adolescent Obesity with Somatic Indicators of Stress, Inflammation, and Dysmetabolism before and after Intervention: A Meta-Analysis
Journal of Personalized Medicine · 4 authors, 4 centres
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This meta-analysis of interventions in overweight or obese children and adolescents found that diet, exercise, or drug interventions significantly reduced body fat and insulin levels, increased adiponectin, and lowered diastolic blood pressure, with trends toward reducing leptin, glucose, and HOMA-IR.
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The analysis found significant reductions in body fat percentage and circulating insulin levels, a significant increase in adiponectin levels, and a significant reduction in diastolic blood pressure compared to control groups. Trends toward improvement were noted for leptin, glucose, and HOMA-IR, though these did not reach statistical significance. The authors concluded that interventions can help re-establish metabolic homeostasis. Key limitations included small study sample sizes (mostly under 100 participants), heterogeneity in intervention duration and type, and a lack of analysis accounting for age or sex differences, which may affect the generalizability of the findings.
