SEARCHNARRATIVE_REVIEWbiomedical research, preclinical research

narrative_review·biomedical research, preclinical research, research methods, ophthalmology·PMC10144389

Chitosan: A Potential Biopolymer in Drug Delivery and Biomedical Applications

Pharmaceutics · 10 authors, 3 centres

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TL;DR

This narrative review summarizes the properties, extraction methods, and diverse biomedical applications of chitosan, a biopolymer derived from chitin.

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301 CHARS

It details various chemical and biological extraction techniques from different sources, explaining processes like demineralization and deproteinization. Limitations include the need for further research to improve material stability, reproducibility, and to explore combinations with other materials.

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narrative_review

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biomedical research

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ORIGINAL PAPER

PMC10144389

Chitosan: A Potential Biopolymer in Drug Delivery and Biomedical Applications

Pharmaceutics

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ABSTRACT

Chitosan, a biocompatible and biodegradable polysaccharide derived from chitin, has surfaced as a material of promise for drug delivery and biomedical applications. Different chitin and chitosan extraction techniques can produce materials with unique properties, which can be further modified to enhance their bioactivities. Chitosan-based drug delivery systems have been developed for various routes of administration, including oral, ophthalmic, transdermal, nasal, and vaginal, allowing for targeted and sustained release of drugs. Additionally, chitosan has been used in numerous biomedical applications, such as bone regeneration, cartilage tissue regeneration, cardiac tissue regeneration, corneal regeneration, periodontal tissue regeneration, and wound healing. Moreover, chitosan has also been utilized in gene delivery, bioimaging, vaccination, and cosmeceutical applications. Modified chitosan derivatives have been developed to improve their biocompatibility and enhance their properties, resulting in innovative materials with promising potentials in various biomedical applications. This article summarizes the recent findings on chitosan and its application in drug delivery and biomedical science.

CITATION EXPORT

Nimeet Desai, Dhwani Rana, Sagar Salave et al.. Chitosan: A Potential Biopolymer in Drug Delivery and Biomedical Applications. Pharmaceutics. (2023). https://doi.org/10.3390/pharmaceutics15041313

AUTHORS

10 · 3 CENTRES

Nimeet Desai, Dhwani Rana, Sagar Salave, Raghav Gupta, Pranav Patel, Bharathi Karunakaran, Amit Sharma, Jyotsnendu Giri, Derajram Benival, Nagavendra Kommineni

1Department of Biomedical Engineering, Indian Institute of Technology Hyderabad, Kandi 502285, India; [email protected] (N.D.); [email protected] (J.G.)
2National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad 382355, India; [email protected] (D.R.); [email protected] (S.S.); [email protected] (R.G.); [email protected] (P.P.); [email protected] (B.K.); [email protected] (A.S.); [email protected] (D.B.)
3Center for Biomedical Research, Population Council, New York, NY 10065, USA

EDITOR / REVIEWER

Giyoong Tae