Chitosan-Based Biomaterials for Tissue Regeneration

Pharmaceutics · 8 authors, 1 centre

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TL;DR

A central finding is that chitosan lacks sufficient mechanical strength and electrical conductivity, which is addressed by combining it with synthetic polymers to improve biomechanical properties.

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A central finding is that chitosan lacks sufficient mechanical strength and electrical conductivity, which is addressed by combining it with synthetic polymers to improve biomechanical properties. The analysis is based on a synthesis of prior studies, not new primary data.

STUDY TYPE

narrative_review

SPECIALTY

biomedical research

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AI pipeline

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ORIGINAL PAPER

PMC10055885

Chitosan-Based Biomaterials for Tissue Regeneration

Pharmaceutics

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ABSTRACT

Abstract Chitosan is a chitin-derived biopolymer that has shown great potential for tissue regeneration and controlled drug delivery. It has numerous qualities that make it attractive for biomedical applications such as biocompatibility, low toxicity, broad-spectrum antimicrobial activity, and many others. Importantly, chitosan can be fabricated into a variety of structures including nanoparticles, scaffolds, hydrogels, and membranes, which can be tailored to deliver a desirable outcome. Composite chitosan-based biomaterials have been demonstrated to stimulate in vivo regeneration and the repair of various tissues and organs, including but not limited to, bone, cartilage, dental, skin, nerve, cardiac, and other tissues. Specifically, de novo tissue formation, resident stem cell differentiation, and extracellular matrix reconstruction were observed in multiple preclinical models of different tissue injuries upon treatment with chitosan-based formulations. Moreover, chitosan structures have been proven to be efficient carriers for medications, genes, and bioactive compounds since they can maintain the sustained release of these therapeutics. In this review, we discuss the most recently published applications of chitosan-based biomaterials for different tissue and organ regeneration as well as the delivery of various therapeutics. Keywords: chitosan biomaterials, functionalized polysaccharides, tissue regeneration, tissue engineering, drug delivery, bone regeneration, cartilage regeneration, dental regeneration, cardiac regeneration, nervous regeneration

CITATION EXPORT

Yevgeniy Kim, Zharylkasyn Zharkinbekov, Kamila Raziyeva et al.. Chitosan-Based Biomaterials for Tissue Regeneration. Pharmaceutics. (2023). https://doi.org/10.3390/pharmaceutics15030807

AUTHORS

8 · 1 CENTRES

Yevgeniy Kim, Zharylkasyn Zharkinbekov, Kamila Raziyeva, Laura Tabyldiyeva, Kamila Berikova, Dias Zhumagul, Kamila Temirkhanova, Arman Saparov

1Department of Medicine, School of Medicine, Nazarbayev University, Nur-Sultan 010000, Kazakhstan