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TL;DR
This narrative review examines the heterogeneity of commercial chow diets used in rodent aging studies, which is often overlooked as a source of biological variability.
GeroScience · 6 authors, 4 centres
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This narrative review examines the heterogeneity of commercial chow diets used in rodent aging studies, which is often overlooked as a source of biological variability.
This narrative review examines the heterogeneity of commercial chow diets used in rodent aging studies, which is often overlooked as a source of biological variability. The review discusses how factors like heat treatment for sterilization can alter nutrient bioavailability and highlights that existing diets, such as AIN-93, were developed for growth and maintenance in younger animals, not specifically for aging studies. The authors conclude that detailed reporting of diet composition and source is critical for improving reproducibility in geroscience research.