SEARCHNARRATIVE_REVIEWdermatology, immunology

narrative_review·dermatology, immunology, preclinical research, biomedical research, systematic review·PMC10051430

Circadian Oscillations in Skin and Their Interconnection with the Cycle of Life

International Journal of Molecular Sciences · 2 authors, 3 centres

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TL;DR

This narrative review describes the molecular circadian clock machinery in skin and its links to skin homeostasis, immunology, and aging.

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This is a narrative review synthesizing existing literature on circadian rhythms in skin. It describes the molecular components of the circadian clock, factors that entrain it, and its connection to immunological processes and skin homeostasis. The review discusses how circadian desynchrony, from factors like intrinsic aging or external stressors, may disrupt skin function and contribute to conditions like atopic skin. It presents changes in skin over the lifespan and the potential for future strategies to combat desynchrony. A central point is that resynchronizing the cellular circadian clock could benefit stress mediation and immune regulation. Limitations include that this is a synthesis without original data, and the potential for circadian modulations are not yet thoroughly characterized.

STUDY TYPE

narrative_review

SPECIALTY

dermatology

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ORIGINAL PAPER

PMC10051430

Circadian Oscillations in Skin and Their Interconnection with the Cycle of Life

International Journal of Molecular Sciences

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ABSTRACT

Periodically oscillating biological processes, such as circadian rhythms, are carefully concerted events that are only beginning to be understood in the context of tissue pathology and organismal health, as well as the molecular mechanisms underlying these interactions. Recent reports indicate that light can independently entrain peripheral circadian clocks, challenging the currently prevalent hierarchical model. Despite the recent progress that has been made, a comprehensive overview of these periodic processes in skin is lacking in the literature. In this review, molecular circadian clock machinery and the factors that govern it have been highlighted. Circadian rhythm is closely linked to immunological processes and skin homeostasis, and its desynchrony can be linked to the perturbation of the skin. The interplay between circadian rhythm and annual, seasonal oscillations, as well as the impact of these periodic events on the skin, is described. Finally, the changes that occur in the skin over a lifespan are presented. This work encourages further research into the oscillating biological processes occurring in the skin and lays the foundation for future strategies to combat the adverse effects of desynchrony, which would likely have implications in other tissues influenced by periodic oscillatory processes.

CITATION EXPORT

Andrew Salazar, Jörg von Hagen. Circadian Oscillations in Skin and Their Interconnection with the Cycle of Life. International Journal of Molecular Sciences. (2023). https://doi.org/10.3390/ijms24065635

AUTHORS

2 · 3 CENTRES

Andrew Salazar, Jörg von Hagen

1Merck KGaA, Frankfurter Strasse 250, 64293 Darmstadt, Germany
2Department of Life Science Engineering, University Applied Sciences, Wiesenstrasse 14, 35390 Gießen, Germany
3ryon—GreenTech Accelerator Gernsheim GmbH, Mainzer Str. 41, 64579 Gernsheim, Germany

EDITOR / REVIEWER

Grzegorz Wegrzyn, Melitta Schachner, Giulio Gabbiani