SEARCHNARRATIVE_REVIEWoncology, biomedical research

narrative_review·oncology, biomedical research, preclinical research, pulmonology·PMC10450211

Circular RNAs: novel actors of Wnt signaling pathway in lung cancer progression

EXCLI Journal · 8 authors, 7 centres

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TL;DR

This narrative review summarizes how circular RNAs (circRNAs) regulate the Wnt/β-catenin signaling pathway, influencing lung cancer progression through molecular mechanisms like miRNA sponging. The central conclusion is that circRNAs represent potential targets for new lung cancer therapies and biomarkers.

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387 CHARS

The authors describe mechanisms by which circRNAs act as miRNA sponges or interact with pathway components to regulate genes like ITCH, DKK1, and LRP, thereby influencing cancer cell growth, migration, and metastasis. The implications suggest that targeting circRNA-mediated regulation of the Wnt/β-catenin pathway could offer novel therapeutic and diagnostic strategies for lung cancer.

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narrative_review

SPECIALTY

oncology

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AI pipeline

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100% · A

ORIGINAL PAPER

PMC10450211

Circular RNAs: novel actors of Wnt signaling pathway in lung cancer progression

EXCLI Journal

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ABSTRACT

Abstract Circular RNAs (CircRNAs) are a class of regulatory RNA transcripts, which are ubiquitously expressed in eukaryotes. CircRNA dysregulation has been shown to disrupt the interaction of the Wnt/β-catenin pathway, which regulates several biological processes involved in tumorigenesis, thereby contributing to the development and progression of cancer. Interactions of tumor-derived circRNAs with the Wnt/β-catenin signaling pathway provide both clinical diagnostic biomarkers and promising therapeutic targets. In this review, we outlined current evidence on the roles of circRNAs associated with the Wnt/β-catenin pathway in regulating lung cancer formation and development. We believe that our findings will assist in the advancement or establishment of circRNA-based lung cancer therapeutic approaches. Keywords: CircRNA, Wnt, lung cancer, signaling cascades, mechanism

CITATION EXPORT

Mina Alimohammadi, Yasaman Gholinezhad, Vahide Mousavi et al.. Circular RNAs: novel actors of Wnt signaling pathway in lung cancer progression. EXCLI Journal. (2023). https://doi.org/10.17179/excli2023-6209

AUTHORS

8 · 7 CENTRES

Mina Alimohammadi, Yasaman Gholinezhad, Vahide Mousavi, Samaneh Kahkesh, Malihe Rezaee, Alireza Yaghoobi, Alireza Mafi, Mahmood Araghi

1Student Research Committee, Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
4Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran
5Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
6Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
7Department of Pathology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran