World Journal of Stem Cells · 3 authors, 5 centres
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This narrative review summarizes the properties and potential clinical applications of dental follicle stem cells (DFSCs). It concludes that DFSCs have natural advantages and promising translational value for treating oral and neurological diseases based on preclinical evidence.
This narrative review summarizes properties and preclinical findings for dental follicle stem cells (DFSCs). It describes DFSCs as originating from the craniofacial neural crest, exhibiting dental-like differentiation potential and neuro-ectodermal features. The review discusses strategies for clinical translation, including combining DFSCs with scaffolds for tissue engineering and the potential for cryopreservation. It outlines future requirements for clinical application, such as establishing potency assessments, optimizing scaffolds, and using bioactive factors to enhance function. The authors conclude DFSCs hold great clinical prospects, but emphasize that key points like potency assessment and scaffold selection need further investigation.
