Clinical applications of stem cell-derived exosomes
Signal Transduction and Targeted Therapy · 6 authors, 6 centres
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FIDELITY 100%
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The authors describe mechanisms of action such as tissue regeneration, anti-inflammation, and immunomodulation, mediated through molecular pathways like Wnt/β-catenin and PTEN/PI3K/Akt/HIF-1α.
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The authors describe mechanisms of action such as tissue regeneration, anti-inflammation, and immunomodulation, mediated through molecular pathways like Wnt/β-catenin and PTEN/PI3K/Akt/HIF-1α. The review highlights demonstrated potential in treating conditions across orthopedic, neurosurgery, plastic, and other surgical fields, based on preclinical models. Limitations include the need for scalable production protocols, optimized delivery methods beyond systemic administration, and the exploration of a wider disease spectrum. Implications suggest that overcoming these challenges could accelerate the clinical translation of exosome therapy.
