SEARCHCROSS-SECTIONALendocrinology, obstetrics and gynecology

cross-sectional·endocrinology, obstetrics and gynecology, internal medicine·PMC10643327

Clinical Phenotypes of PCOS: a Cross-Sectional Study

Reproductive Sciences · 9 authors, 2 centres

AI SUMMARY

FIDELITY 100%

This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.

AGENT 01 · STRUCTURED SUMMARY

TRACE TO SOURCE

“

TL;DR

This cross-sectional study analyzed clinical and biochemical data from women with PCOS to identify and validate three distinct phenotypes (A, B, C) with different underlying hormonal and metabolic pathways.

Full summary

783 CHARS

This cross-sectional study aimed to characterize and validate clinical phenotypes in women with PCOS. Using data from two independent cohorts (Kuwait and Rotterdam), the researchers identified three distinct phenotypes: Phenotype A (neuroendocrine dysfunction, high LH, excess ovarian androgens), Phenotype B (metabolic dysfunction, obesity, insulin resistance), and Phenotype C (adrenal hyperandrogenism, regular cycles). The classification was supported by cluster analyses from prior independent studies. The study links each phenotype to a primary biochemical pathway and putative genetics, such as DENND1A for A, Grb14 for B, and an unclear driver for C. The findings suggest that these phenotypes may guide more targeted research and personalized treatment strategies for PCOS.

STUDY TYPE

cross-sectional

SPECIALTY

endocrinology

SUMMARISED BY

AI pipeline

FIDELITY CHECK

100% · A

ORIGINAL PAPER

PMC10643327

Clinical Phenotypes of PCOS: a Cross-Sectional Study

Reproductive Sciences

READ THE FULL PAPER

ABSTRACT

This cross-sectional study examines the Doi-Alshoumer PCOS clinical phenotype classification in relation to measured clinical and biochemical characteristics of women with polycystic ovary syndrome (PCOS). Two cohorts of women (Kuwait and Rotterdam) diagnosed with PCOS (FAI > 4.5%) were examined. These phenotypes were created using neuroendocrine dysfunction (IRMA LH/FSH ratio > 1 or LH > 6 IU/L) and menstrual cycle status (oligo/amenorrhea) to create three phenotypes: (A) neuroendocrine dysfunction and oligo/amenorrhea, (B) without neuroendocrine dysfunction but with oligo/amenorrhea, and (C) without neuroendocrine dysfunction and with regular cycles. These phenotypes were compared in terms of hormonal, biochemical, and anthropometric measures. The three suggested phenotypes (A, B, and C) were shown to be sufficiently distinct in terms of hormonal, biochemical, and anthropometric measures. Patients who were classified as phenotype A had neuroendocrine dysfunction, excess LH (and LH/FSH ratio), irregular cycles, excess A4, infertility, excess T, highest FAI and E2, and excess 17αOHPG when compared to the other phenotypes. Patients classified as phenotype B had irregular cycles, no neuroendocrine dysfunction, obesity, acanthosis nigricans, and insulin resistance. Lastly, patients classified as phenotype C had regular cycles, acne, hirsutism, excess P4, and the highest P4 to E2 molar ratio. The differences across phenotypes suggested distinct phenotypic expression of this syndrome, and the biochemical and clinical correlates of each phenotype are likely to be useful in the management of women with PCOS. These phenotypic criteria are distinct from criteria used for diagnosis. Supplementary Information The online version contains supplementary material available at 10.1007/s43032-023-01262-4.

CITATION EXPORT

Abdalla Moustafa Elsayed, Latifa Saad Al-Kaabi, Noora Mohammed Al-Abdulla et al.. Clinical Phenotypes of PCOS: a Cross-Sectional Study. Reproductive Sciences. (2023). https://doi.org/10.1007/s43032-023-01262-4

AUTHORS

9 · 2 CENTRES

Abdalla Moustafa Elsayed, Latifa Saad Al-Kaabi, Noora Mohammed Al-Abdulla, Moza Salem Al-Kuwari, Asmaa Abdulsamad Al-Mulla, Raghad Shaher Al-Shamari, Ahmed Khaled Alhusban, Ali Ahmed AlNajjar, Suhail A. R. Doi

1https://ror.org/00yhnba62grid.412603.20000 0004 0634 1084College of Medicine, QU Health, Qatar University, Doha, Qatar
2https://ror.org/00yhnba62grid.412603.20000 0004 0634 1084Department of Population Medicine, College of Medicine, QU Health, Qatar University, P.O. Box 2713, Doha, Qatar