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case-control·neurology, hematology, epidemiology, observational study·PMC10405461

Clinical, radiological profile and prognostic role of transcranial color-coded duplex in cerebral venous thrombosis: a case-control study

BMC Neurology · 5 authors, 1 centre

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TL;DR

The most common risk factors were female-specific and hereditary thrombophilia.

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This case-control study conducted at Cairo University Hospitals from 2020 to 2022 investigated the clinical and radiological profiles, risk factors, and the prognostic role of TCCD in 80 CVT patients compared to 80 matched controls. The study found a female predominance with gender-specific risk factors as the most common etiology. Among hereditary thrombophilias, homozygous factor V Leiden mutation and antithrombin III deficiency were most common. Headache was the most frequent presentation, and transverse sinus thrombosis was the most common radiological finding. A positive, though not statistically significant, correlation was observed between these flow velocities and the modified Rankin Scale at 3 months.

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case-control

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neurology

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ORIGINAL PAPER

PMC10405461

Clinical, radiological profile and prognostic role of transcranial color-coded duplex in cerebral venous thrombosis: a case-control study

BMC Neurology

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ABSTRACT

Abstract Background Cerebral venous thrombosis is a rare type of stroke, occurring more among young individuals. The presentation is highly variable, and this can delay diagnosis and management, thereby affecting outcome. The aim is to study the clinical, radiological profile, risk factors for cerebral venous thrombosis (CVT) and the role of transcranial color-coded duplex (TCCD) in CVT prognosis among Egyptian patients. Methods Eighty CVT patients and 80 normal healthy individuals were included. Magnetic resonance imaging, magnetic resonance venography, and genetic thrombophilia tests were done for patients. Deep cerebral venous system was evaluated using B-mode transcranial color-coded duplex (TCCD) for both groups. Results Showed female predominance with gender specific risk factors being the most common etiology. The most common hereditary thrombophilia was homozygous factor V Leiden mutation and anti-thrombin III (AT III). Headache was the most common presentation. Forty-three patients had transverse sinus thrombosis. Regarding TCCD, there was an increase in mean blood flow velocities, peak flow velocities and end diastolic flow velocities in deep middle cerebral vein and basal veins in CVT group compared to control group. There was a positive correlation not reaching statistical significance between flow velocities in the deep venous system and modified Rankin Scale. Conclusion Clinical presentation is extremely variable. In our population, homozygous factor V Leiden mutation and AT III deficiency were the most common. Increased deep cerebral venous system flow velocities using TCCD in patients with CVT reflect their venous hemodynamic state. Keywords: Cerebral venous thrombosis, Hereditary thrombophilia, Transcranial color-coded duplex, Venous velocities

CITATION EXPORT

Alshaimaa M Aboul fotouh, Sadek Mohamed Helmy, Husam S Mourad et al.. Clinical, radiological profile and prognostic role of transcranial color-coded duplex in cerebral venous thrombosis: a case-control study. BMC Neurology. (2023). https://doi.org/10.1186/s12883-023-03342-z

AUTHORS

5 · 1 CENTRES

Alshaimaa M Aboul fotouh, Sadek Mohamed Helmy, Husam S Mourad, Hadeel Ahmed Abdelbaky, Ghada Hatem

1Department of Neurology, Faculty of medicine, Cairo University, Al-Saraya Street, Al Manial, Cairo, Egypt